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View Structure Prediction Details

Protein: MET7
Organism: Saccharomyces cerevisiae
Length: 548 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MET7.

Description E-value Query
Range
Subject
Range
FOLE_YEAS8 - Folylpolyglutamate synthase OS=Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) GN=...
FOLE_YEAS7 - Folylpolyglutamate synthase OS=Saccharomyces cerevisiae (strain YJM789) GN=MET7 PE=3 SV=1
FOLE_YEAST - Folylpolyglutamate synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MET7 PE=1 SV...
FOLE_YEASL - Folylpolyglutamate synthase OS=Saccharomyces cerevisiae (strain Lalvin QA23) GN=MET7 PE=3 SV=2
MET7 - Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, ...
FOLE_YEAS1 - Folylpolyglutamate synthase OS=Saccharomyces cerevisiae (strain RM11-1a) GN=MET7 PE=3 SV=1
FOLE_YEASZ - Folylpolyglutamate synthase OS=Saccharomyces cerevisiae (strain Zymaflore VL3) GN=MET7 PE=3 SV=2
0.0 [1..548] [1..548]
FOLE_SCHPO - Probable folylpolyglutamate synthase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=met7 ...
SPBC1709.17 - folylpolyglutamate synthase
2.0E-90 [48..545] [7..503]
FOLE_CANAX - Folylpolyglutamate synthase OS=Candida albicans GN=MET7 PE=3 SV=1
4.0E-86 [66..543] [16..510]
FPGS - folylpolyglutamate synthase
2.0E-85 [66..545] [43..584]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
5.0E-84 [65..543] [42..582]
gi|14582587 - gi|14582587|gb|AAK69546.1|AF283647_1 folylpoly-gammaglutamate synthetase precursor [Cricetulus grise...
1.0E-83 [65..543] [42..582]
gi|13529530 - gi|13529530|gb|AAH05484.1| Fpgs protein [Mus musculus]
1.0E-82 [66..543] [1..540]

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Predicted Domain #1
Region A:
Residues: [1-97]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHKGKKNYPN LITSFRMNLK KIILNHDRFS HPERWKTNAL LRFTFVYIKF LFDLMIIKNP  60
   61 LRMVGKTYRD AVTALNSLQS NYANIMAIRQ TGDRKNT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.589 f.13.1 Family A G protein-coupled receptor-like
View Download 0.730 a.24.9 alpha-catenin/vinculin
View Download 0.586 a.7.8 GAT domain
View Download 0.662 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.633 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.583 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.580 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.569 f.15.1 Small-conductance potassium channel
View Download 0.544 d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like
View Download 0.539 a.47.2 t-snare proteins
View Download 0.532 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.511 a.29.2 Bromodomain
View Download 0.509 a.47.2 t-snare proteins
View Download 0.498 a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.498 a.47.2 t-snare proteins
View Download 0.496 a.142.1 PTS-regulatory domain, PRD
View Download 0.488 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.485 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.476 a.7.1 Spectrin repeat
View Download 0.464 a.24.3 Cytochromes
View Download 0.439 a.74.1 Cyclin-like
View Download 0.438 d.58.35 Pseudouridine synthase
View Download 0.429 a.1.1 Globin-like
View Download 0.425 d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.425 a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.420 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.417 a.118.1 ARM repeat
View Download 0.407 a.47.2 t-snare proteins
View Download 0.406 a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.393 a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.389 a.71.2 Helical domain of Sec23/24
View Download 0.385 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.384 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.373 a.24.15 FAD-dependent thiol oxidase
View Download 0.371 a.16.1 S15/NS1 RNA-binding domain
View Download 0.369 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.368 a.177.1 Sigma2 domain of RNA polymerase sigma factors
View Download 0.364 a.4.5 "Winged helix" DNA-binding domain
View Download 0.363 d.6.1 Prion-like
View Download 0.361 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.360 a.4.3 ARID-like
View Download 0.358 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.357 a.4.1 Homeodomain-like
View Download 0.354 a.4.12 TrpR-like
View Download 0.353 a.25.1 Ferritin-like
View Download 0.346 a.4.12 TrpR-like
View Download 0.342 i.11.1 Computational models partly based on NMR data
View Download 0.342 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.336 a.7.8 GAT domain
View Download 0.335 f.15.1 Small-conductance potassium channel
View Download 0.334 a.24.17 Group V grass pollen allergen
View Download 0.331 a.7.7 BAG domain
View Download 0.329 a.24.2 Aspartate receptor, ligand-binding domain
View Download 0.329 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.324 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.324 a.24.17 Group V grass pollen allergen
View Download 0.324 a.7.7 BAG domain
View Download 0.323 a.25.1 Ferritin-like
View Download 0.320 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.315 a.4.12 TrpR-like
View Download 0.314 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.312 a.47.2 t-snare proteins
View Download 0.311 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.310 a.47.2 t-snare proteins
View Download 0.310 f.15.1 Small-conductance potassium channel
View Download 0.307 a.112.1 Description not found.
View Download 0.305 a.118.1 ARM repeat
View Download 0.301 a.118.8 TPR-like
View Download 0.301 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.301 a.74.1 Cyclin-like
View Download 0.299 f.14.1 Voltage-gated potassium channels
View Download 0.292 a.47.2 t-snare proteins
View Download 0.288 a.7.7 BAG domain
View Download 0.287 a.23.4 Mitochondrial import receptor subunit Tom20
View Download 0.287 f.31.1 Photosystem I reaction center subunit XI, PsaL
View Download 0.286 a.7.6 Ribosomal protein S20
View Download 0.278 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.277 a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.277 d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like
View Download 0.274 d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.274 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.274 a.7.7 BAG domain
View Download 0.274 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.274 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.273 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.271 a.142.1 PTS-regulatory domain, PRD
View Download 0.270 a.1.1 Globin-like
View Download 0.270 a.7.7 BAG domain
View Download 0.269 f.17.1 F1F0 ATP synthase subunit C
View Download 0.265 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.262 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.262 a.74.1 Cyclin-like
View Download 0.260 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.258 f.14.1 Voltage-gated potassium channels
View Download 0.255 a.5.4 Elongation factor TFIIS domain 2
View Download 0.254 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.253 a.47.2 t-snare proteins
View Download 0.253 a.24.3 Cytochromes
View Download 0.252 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.250 a.24.17 Group V grass pollen allergen
View Download 0.250 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.250 a.39.1 EF-hand
View Download 0.248 a.47.2 t-snare proteins
View Download 0.248 a.7.1 Spectrin repeat
View Download 0.248 f.32.1 a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.247 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.244 a.24.9 alpha-catenin/vinculin
View Download 0.244 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.241 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.241 d.208.1 MTH1598-like
View Download 0.240 a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.240 a.51.1 Cytochrome c oxidase subunit h
View Download 0.239 a.24.9 alpha-catenin/vinculin
View Download 0.238 a.118.8 TPR-like
View Download 0.237 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.237 a.118.11 Cytochrome c oxidase subunit E
View Download 0.237 d.150.1 4'-phosphopantetheinyl transferase
View Download 0.235 a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.235 a.69.3 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
View Download 0.234 f.13.1 Family A G protein-coupled receptor-like
View Download 0.233 a.23.4 Mitochondrial import receptor subunit Tom20
View Download 0.233 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.233 d.91.1 N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1
View Download 0.233 a.85.1 Hemocyanin, N-terminal domain
View Download 0.231 a.74.1 Cyclin-like
View Download 0.229 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.229 a.7.8 GAT domain
View Download 0.229 a.22.1 Histone-fold
View Download 0.228 a.4.1 Homeodomain-like
View Download 0.228 a.11.2 Second domain of FERM
View Download 0.228 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.227 a.2.3 Chaperone J-domain
View Download 0.224 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.223 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.222 f.17.1 F1F0 ATP synthase subunit C
View Download 0.221 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.221 a.16.1 S15/NS1 RNA-binding domain
View Download 0.220 a.177.1 Sigma2 domain of RNA polymerase sigma factors
View Download 0.218 a.24.3 Cytochromes
View Download 0.216 a.4.5 "Winged helix" DNA-binding domain
View Download 0.216 a.26.1 4-helical cytokines
View Download 0.216 a.144.1 PABC (PABP) domain
View Download 0.215 a.69.1 C-terminal domain of alpha and beta subunits of F1 ATP synthase
View Download 0.214 a.118.1 ARM repeat
View Download 0.214 a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.213 a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.211 a.2.6 Effector domain of the protein kinase pkn/prk1
View Download 0.211 a.47.2 t-snare proteins
View Download 0.210 a.46.1 Methionine synthase domain
View Download 0.209 a.112.1 Description not found.
View Download 0.209 f.21.2 Fumarate reductase respiratory complex transmembrane subunits
View Download 0.209 a.24.3 Cytochromes
View Download 0.209 a.47.2 t-snare proteins
View Download 0.208 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.207 a.118.1 ARM repeat
View Download 0.206 i.1.1 Ribosome and ribosomal fragments
View Download 0.205 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.205 f.16.1 Gated mechanosensitive channel
View Download 0.204 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.203 a.24.4 Hemerythrin
View Download 0.203 a.149.1 RNase III endonuclease catalytic domain
View Download 0.203 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.202 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.202 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.201 a.28.1 ACP-like
View Download 0.200 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3

Predicted Domain #2
Region A:
Residues: [98-379]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLLEMHEWS RRIGYSASDF NKLNIVHITG TKGKGSTAAF TSSILGQYKE QLPRIGLYTS  60
   61 PHLKSVRERI RINGEPISEE KFAKYFFEVW DRLDSTTSSL DKFPHMIPGS KPGYFKFLTL 120
  121 LSFHTFIQED CKSCVYEVGV GGELDSTNII EKPIVCGVTL LGIDHTFMLG DTIEEIAWNK 180
  181 GGIFKSGAPA FTVEKQPPQG LTILKERAEE RKTTLTEVPP FKQLENVKLG IAGEFQKSNA 240
  241 SLAVMLASEI LHTSNILEEK IKCSSNASIP EKFIIGLQNT KW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 275.38764
Match: 1fgs__
Description: Folylpolyglutamate synthetase, C-terminal domain; Folylpolyglutamate synthetase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [380-548]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGRCQVLEKG KNVWYIDGAH TKDSMVAAST WFRDMVRLSK RKKILLFNQQ SRDANALVNN  60
   61 LYSSVSPEIT FDDVIFTTNV TWKSGSYSAD LVSMNTSQED VEKLKVQESL VKNWNKIDDN 120
  121 RAKTHVTASI EEANELIETL YDEPADIFVT GSLHLVGGLL VVFDRIDVK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 275.38764
Match: 1fgs__
Description: Folylpolyglutamate synthetase, C-terminal domain; Folylpolyglutamate synthetase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle