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Protein Overview: KIN4

General Information:
Name(s) found: KIN4 / YOR233W [SGD]
Description(s) found:
Found 29 descriptions.
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  • Serine/threonine protein kinase that inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 800 amino acids

    Gene Ontology:
    Cellular Component: cellular bud neck [IDALink to PubMed article]
    cell cortex [IDALink to PubMed article]
    spindle pole body [IDALink to PubMed article]
    Biological Process: mitotic cell cycle spindle orientation checkpoint [IGILink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: protein kinase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASVPKRHTY GGNVVTDRDR HSLQRNNEIL HPIHKNQRKH ATFGPYIIGS TLGEGEFGKV  60
   61 KLGWTKASSS NEVPKQVAIK LIRRDTIKKD ADKEIKIYRE INALKHLTHP NIIYLEEVLQ 120
  121 NSKYIGIVLE FVSGGEFYKY IQRKRRLKES SACRLFAQLI SGVNYMHYKG LVHRDLKLEN 180
  181 LLLDKHENLV ITDFGFVNEF FEDNELMKTS CGSPCYAAPE LVVSTKAYEA RKADVWSCGV 240
  241 ILYAMLAGYL PWDDDHENPT GDDIARLYKY ITQTPLKFPE YITPIPRDLL RRILVPNPRR 300
  301 RINLQTIKRH VWLKPHEAFL SIQPNYWDEH LQKERPKPPN KGDVGRHSTY SSSASSYSKS 360
  361 RDRNSLIIES TLEQHRMSPQ LATSRPASPT FSTGSKVVLN DTKNDMKESN INGERTSASC 420
  421 RYTRDSKGNG QTQIEQVSAR HSSRGNKHTS VAGLVTIPGS PTTARTRNAP SSKLTEHVKD 480
  481 SSQTSFTQEE FHRIGNYHVP RSRPRPTSYY PGLSRNTADN SLADIPVNKL GSNGRLTDAK 540
  541 DPVPLNAIHD TNKATISNNS IMLLSEGPAA KTSPVDYHYA IGDLNHGDKP ITEVIDKINK 600
  601 DLTHKAAENG FPRESIDPES TSTILVTKEP TNSTDEDHVE SQLENVGHSS NKSDASSDKD 660
  661 SKKIYEKKRF SFMSLYSSLN GSRSTVESRT SKGNAPPVSS RNPSGQSNRS NIKITQQQPR 720
  721 NLSDRVPNPD KKINDNRIRD NAPSYAESEN PGRSVRASVM VSTLREENRS ELSNEGNNVE 780
  781 AQTSTARKVL NFFKRRSMRV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) KIN4 YMR010W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data KIN4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..101]
    [115..131]
    [344..416]    		 PSI-BLAST 442.9897 cAMP-dependent PK, catalytic subunit
    2 View Details [102..114]
    [132..343]    		 PSI-BLAST 442.9897 cAMP-dependent PK, catalytic subunit
    3 View Details [417..800] deduced N/A No confident structure predictions are available.
    4 View Details [558..664] deduced N/A No confident structure predictions are available.
    5 View Details [665..800] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle