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Protein Overview: THI80

General Information:
Name(s) found: THI80 / YOR143C [SGD]
Description(s) found:
Found 37 descriptions.
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  • Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 319 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: thiamin diphosphate biosynthetic process [IMPLink to PubMed article][TASLink to PubMed article]
    Molecular Function: thiamin diphosphokinase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEECIENPE RIKIGTDLIN IRNKMNLKEL IHPNEDENST LLILNQKIDI PRPLFYKIWK  60
   61 LHDLKVCADG AANRLYDYLD DDETLRIKYL PNYIIGDLDS LSEKVYKYYR KNKVTIIKQT 120
  121 TQYSTDFTKC VNLISLHFNS PEFRSLISNK DNLQSNHGIE LEKGIHTLYN TMTESLVFSK 180
  181 VTPISLLALG GIGGRFDQTV HSITQLYTLS ENASYFKLCY MTPTDLIFLI KKNGTLIEYD 240
  241 PQFRNTCIGN CGLLPIGEAT LVKETRGLKW DVKNWPTSVV TGRVSSSNRF VGDNCCFIDT 300
  301 KDDIILNVEI FVDKLIDFL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data THI80 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..26]
    [228..308]    		 PSI-BLAST 10109.0 Thiamin pyrophosphokinase, substrate-binding domain; Thiamin pyrophosphokinase, catalytic domain
    2 View Details [27..227]
    [309..319]    		 PSI-BLAST 10109.0 Thiamin pyrophosphokinase, substrate-binding domain; Thiamin pyrophosphokinase, catalytic domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • thiamin diphosphokinase activity
    		•  3.17820968990148 bayes_pls_golite062009
  • catalytic activity
    		•  0.902495165806215 bayes_pls_golite062009
  • diphosphotransferase activity
    		•  0.763669021538822 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.0461369092625173 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle