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Protein Overview: MSA1

General Information:
Name(s) found: MSA1 / YOR066W [SGD]
Description(s) found:
Found 32 descriptions.
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  • Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 629 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKSMIKKRG RPPITKDYPN PLQSPMAHSS MQVQKQGPHS FAKPLMKVGQ SSPSPNKRRL  60
   61 SIDHHHNLAA TTRKGRYRGV LLSTPTKKSS TNGSTPISTP SSNDSYNNTV FSETRKTFLQ 120
  121 SSPPIMTSSP AFQKKNDYMF PSQEQFKLSL TITESGKAVI AGSLPFSPSS KSSHLMNNNN 180
  181 KKIMQNEKIH KGSKKNAPKF EKRRILSLLK QMKNEKYCDT DTLPEAPPAK PSRSDIIDTE 240
  241 LPTIIETSAS PIGSARNNNI LLSQPPQSPP SSAQLKPPST PKSSLQFRMG FTPNVALNSV 300
  301 SLSDTISKST NAVGASNNNN QNGNSISNIA DANTLLTLTN SPGVFLSPRN KMLPKSTTAS 360
  361 NEQQQEFVFK FSSGDPLLLT DDADGNWPEM LFNVSNTPRR QKCFNTPPSW INFGSPGLFS 420
  421 PPRSSNVMVN GTTVATASDS GNVHRQLQAQ LEAQVQVQSQ SNSPTQRQQQ QRQFQIPPPH 480
  481 INMNSSPPQI NIASPPHQSM SRVSSIYFNK EKTTTGVANM LGNTKSENLQ PPANLFTAAH 540
  541 GPSTPRNQEF QLPTLIECTP LIQQTMNGSL GTKYIPGTSI SNSATPNLHG FPVGTGKAPS 600
  601 SFDDSLKQNP YSNKQDDART ALKRLIDDQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run NOP9 No Comments Hazbun TR, et al. (2003)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen MSA1 YLR297W 2 Unpublished Fields Lab Data
    View Screen CLB2 MSA1 2 Unpublished Fields Lab Data
    View Screen CLB5 MSA1 2 Unpublished Fields Lab Data
    View Screen CDC28 MSA1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..547] ORFEUS 9.7 EGF receptor extracellular domain; EGF receptor Cys-rich domains
    2 View Details [548..629] ORFEUS 7.37 Receptor protein-tyrosine kinase Erbb-3 extracellular domain; Receptor protein-tyrosine kinase Erbb-3 Cys-rich domains

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.99921478264464 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.0106414707696 bayes_pls_golite062009
  • protein binding
    		•  1.84406396813419 bayes_pls_golite062009
  • growth factor binding
    		•  1.34776702960536 bayes_pls_golite062009
  • insulin-like growth factor binding
    		•  0.575677181912068 bayes_pls_golite062009
  • catalytic activity
    		•  0.286333564590773 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  2.99921478264464 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.0106414707696 bayes_pls_golite062009
  • protein binding
    		•  1.84406396813419 bayes_pls_golite062009
  • growth factor binding
    		•  1.34776702960536 bayes_pls_golite062009
  • insulin-like growth factor binding
    		•  0.575677181912068 bayes_pls_golite062009
  • catalytic activity
    		•  0.286333564590773 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle