Protein Overview: TIR4

General Information:
Name(s) found:	TIR4 / YOR009W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|74655039\|sp\|Q12218.1\|TIR4_YEAST RecName: Full=Cell wall protein TIR4; AltName: Full=TIP1-related protein 4; Flags: Precursor [NCBI NR] gi\|6324583\|ref\|NP_014652.1\| Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock; Tir4p [Saccharomyces cerevis [NCBI NR] pir\|\|S61993 probable membrane protein YOR009w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1420104\|emb\|CAA99197.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] gi\|1151005\|gb\|AAC49489.1\| hypothetical protein UNB487 [NCBI NR] Cell wall protein TIR4 OS=Saccharomyces cerevisiae GN=TIR4 PE=1 SV=1 [Swiss-Prot] TIR4 Cell wall mannoprotein, involved in cell wall maintanance [mips] Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock [SGD] >Q12218 (Q12218) Hypothetical protein YOR009W [4932.FASTACCERV.txt] Chr XV from 344334-345797 [hmr_yeast5_DM3-1_pombe.fasta] TIR4, Chr XV from 344334-345797 [yeast_orfs2] TIR4 SGDID:S0005535, Chr XV from 344334-345797, Verified ORF [yeastflysequest.fasta] Tir4p [Saccharomyces cerevisiae]gi\|1420104\|emb\|CAA99197.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|2132864\|pir\|\|S61993 probable membrane protein YOR009w - yeast (Saccharomyces cerevisiae)gi\|1151005\|gb\|AAC49489.1\| hypothetical protein UNB48 [nrdb_11152004_Chlamydomonas] (Q12218) Hypothetical protein UNB487 (S.cerevisiae chromosome XV reading frame ORF YOR009w) [cerv4932.FASTAC] TIR4 SGDID:S000005535, Chr XV from 344334-345797, Verified ORF, "Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by col [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] TIR4 SGDID:S000005535, Chr XV from 344335-345798, Verified ORF, "Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by col [yeast-contam.fasta] hypothetical protein UNB487 [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock; Tir4p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] TIR4 SGDID:S000005535, Chr XV from 344335-345798, Verified ORF, "Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Cell wall protein TIR4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TIR4 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] TIR4 SGDID:S000005535, Chr XV from 344335-345798, Genome Release 64-1-1, Verified ORF, "Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock" [yeast-030211-contam.fasta] TIR4 SGDID:S000005535, Chr XV from 344335-345798, Genome Release 64-2-1, Verified ORF, "Cell wall mannoprotein; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins" [20141208_orf_trans.fasta] YOR009W SGDID:S000005535, Chr XV from 344335-345798, Genome Release 64-1-1, Verified ORF, "Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	487 amino acids
Gene Ontology:
Cellular Component:	fungal-type cell wall [IDA]
Biological Process:	biological_process [ND]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAYSKITLLA ALAAIAYAQT QAQINELNVV LDDVKTNIAD YITLSYTPNS GFSLDQMPAG  60
   61 IMDIAAQLVA NPSDDSYTTL YSEVDFSAVE HMLTMVPWYS SRLLPELEAM DASLTTSSSA 120
  121 ATSSSEVASS SIASSTSSSV APSSSEVVSS SVAPSSSEVV SSSVAPSSSE VVSSSVASSS 180
  181 SEVASSSVAP SSSEVVSSSV ASSSSEVASS SVAPSSSEVV SSSVAPSSSE VVSSSVASSS 240
  241 SEVASSSVAP SSSEVVSSSV ASSTSEATSS SAVTSSSAVS SSTESVSSSS VSSSSAVSSS 300
  301 EAVSSSPVSS VVSSSAGPAS SSVAPYNSTI ASSSSTAQTS ISTIAPYNST TTTTPASSAS 360
  361 SVIISTRNGT TVTETDNTLV TKETTVCDYS STSAVPASTT GYNNSTKVST ATICSTCKEG 420
  421 TSTATDFSTL KTTVTVCDSA CQAKKSATVV SVQSKTTGIV EQTENGAAKA VIGMGAGALA 480
  481 AVAAMLL

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		TIR4 ZPR1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RLF2	phosphorylation data - cascade search	Green EM, et al (2005)
View Run	MLP2	#03 Alpha Factor Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SPT2	TIR4	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..123]	Pfam	36.823909	Seripauperin and TIP1 family No confident structure predictions are available.
2	View Details	[124..423]	ORFEUS	12.03	Fibrinogen
3	View Details	[424..487]	ORFEUS	12.23	Fibrinogen
4	View Details	[385..487]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2