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Protein Overview: MCH4

General Information:
Name(s) found: MCH4 / YOL119C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 501 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole membrane [IDALink to PubMed article]
    Biological Process: transport [ISSLink to PubMed article]
    Molecular Function: transporter activity [ISSLink to PubMed article]
    [NOT]monocarboxylic acid transmembrane transporter activity [IGILink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLNIPIIANS KRFLFSKDHE AQSTRDHDVE LETREGPSSG YNPNFNAADA ILKKNSDQVD  60
   61 LDVNKLTNVT SRVLNTPEAS LIYDDDREFP DGGLKAWLVV FGAFMGLVPV FGLINSLGAI 120
  121 ESYISKHQLA NISSSTISWI FSLYLAISFL SCILSGGYFD RNGSIGLMCT GTVIYAGGLF 180
  181 ALANCKSVWQ FILAFSVCSG LGTGILMTPL IGTVATWFLK RRGIATSIST MGGSIGGIVF 240
  241 PIMLRKLYKE VGFQWAIRIL SFICLTCLIC ASVLARERTK PVVQPFKSKA EVAKWYISSV 300
  301 FNWRYFLEGK FLFVAIGASF AESSLTSCAT YLASYSMTRG NTENVAYTMI TASNAVGILG 360
  361 RYIPGYFADK FIGRFNVEII TISMAALFNF VMWLPFGGNT KVLWAYVCLW GFSTGSILSL 420
  421 TPVCIGQISK TTDFGKRYAT VYLLQALVTI PVLPIGGTLI GKGTVANYNH FIIFNSALMA 480
  481 AGAACYIISR HICVGAKLCK F

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..87] MSA 3.260997 View MSA. No confident structure predictions are available.
    2 View Details [88..501] PSI-BLAST 16.09691 No description for 1lviA_ was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transporter activity
    		•  4.09176719149278 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.5865018981083 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.3426261924492 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.29689809004391 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  2.15783210522667 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.94035843948137 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.59419818573076 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.5181741634556 bayes_pls_golite062009
  • secondary active transmembrane transporter activity
    		•  1.22264637452409 bayes_pls_golite062009
  • polyol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • alcohol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • binding
    		•  0.873217664940684 bayes_pls_golite062009
  • glycerol transmembrane transporter activity
    		•  0.812001619402678 bayes_pls_golite062009
  • symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • solute:cation symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • cation:sugar symporter activity
    		•  0.143419068761182 bayes_pls_golite062009
  • sugar:hydrogen symporter activity
    		•  0.143419068761182 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle