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Protein Overview: MSB4

General Information:
Name(s) found: MSB4 / YOL112W [SGD]
Description(s) found:
Found 32 descriptions.
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  • GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 492 amino acids

    Gene Ontology:
    Cellular Component: incipient cellular bud site [IDALink to PubMed article]
    cellular bud tip [IDALink to PubMed article]
    Biological Process: actin filament organization [TASLink to PubMed article]
    Molecular Function: Rab GTPase activator activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIMSSTMSTE AALVPNESVF DTVSSFNEDD ANYSVLDLYD DDDEGDDSST VERKEILTTR  60
   61 ELEKAKAFTS LIMADPENFD RYGFSKKGYF ISQEEYDKWW TEYNRYTERR KKKWENFLLK 120
  121 NKIELHNDNP LVYPARTDEL SKFVRKGIPA EWRGNAWWYF AGGQRQLDAN VGVYDRLKSD 180
  181 CREGAVSGKD MEAIERDLYR TFPDNIHFHK ESFQNGEPAI IRSLRRVLMA FSVYDKTIGY 240
  241 CQSMNFLVGL LLLFMEEEKA FWMLVIITGK YLPGVYESDL EGANVDQGVL VLCIKEYLPE 300
  301 IWSHIESSYM NGNGSTDQIS GPASGEEYLC RLPTLTLCTA SWFMSCFVGV VPIETTLRIW 360
  361 DCLFYEESHF LFKVALGILK LSESEFLESK SQKLFRQYSS YTFGGSNDSD STFKRLKNKI 420
  421 KTQEEADMEI LQVIQNFPKR LLNPNDIFEK VLMKKKVALN GITQEKIDRG REYVAMARNR 480
  481 QRASSRPKER RK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen MSB4 SPA2 2 Drees BL, et al. (2001)
    View Screen PUF3 MSB4 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MSB4 Huh WK, et al. (2003)
    View Data MSB4 Huh WK, et al. (2003)
    View Data MSB4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..91] deduced N/A No confident structure predictions are available.
    2 View Details [92..281]
    [358..431]    		 PSI-BLAST 34.69897 Ypt/Rab-GAP domain of gyp1p
    3 View Details [282..357] PSI-BLAST 34.69897 Ypt/Rab-GAP domain of gyp1p
    4 View Details [432..492] MSA 3.114995 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle