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View Structure Prediction Details

Protein: MSB4
Organism: Saccharomyces cerevisiae
Length: 492 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MSB4.

Description E-value Query
Range
Subject
Range
MSB4 - GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud ...
MSB4_YEAST - GTPase-activating protein MSB4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MSB4 PE=1...
0.0 [1..492] [1..492]
gi|3327166 - gi|3327166|dbj|BAA31651.1| KIAA0676 protein [Homo sapiens]
2.0E-73 [7..490] [392..819]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
3.0E-68 [27..490] [427..841]
gi|9790251, gi|9... - gi|988221|gb|AAA85223.1| Tbc1, gi|9790251|ref|NP_062610.1| TBC1 domain family, member 1 [Mus musculu...
1.0E-67 [16..491] [620..1095]

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Predicted Domain #1
Region A:
Residues: [1-91]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIMSSTMSTE AALVPNESVF DTVSSFNEDD ANYSVLDLYD DDDEGDDSST VERKEILTTR  60
   61 ELEKAKAFTS LIMADPENFD RYGFSKKGYF I

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [92-281]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQEEYDKWWT EYNRYTERRK KKWENFLLKN KIELHNDNPL VYPARTDELS KFVRKGIPAE  60
   61 WRGNAWWYFA GGQRQLDANV GVYDRLKSDC REGAVSGKDM EAIERDLYRT FPDNIHFHKE 120
  121 SFQNGEPAII RSLRRVLMAF SVYDKTIGYC QSMNFLVGLL LLFMEEEKAF WMLVIITGKY 180
  181 LPGVYESDLE 

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [358-431]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RIWDCLFYEE SHFLFKVALG ILKLSESEFL ESKSQKLFRQ YSSYTFGGSN DSDSTFKRLK  60
   61 NKIKTQEEAD MEIL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 34.69897
Match: 1fkmA_
Description: Ypt/Rab-GAP domain of gyp1p
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [282-357]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GANVDQGVLV LCIKEYLPEI WSHIESSYMN GNGSTDQISG PASGEEYLCR LPTLTLCTAS  60
   61 WFMSCFVGVV PIETTL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 34.69897
Match: 1fkmA_
Description: Ypt/Rab-GAP domain of gyp1p
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [432-492]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QVIQNFPKRL LNPNDIFEKV LMKKKVALNG ITQEKIDRGR EYVAMARNRQ RASSRPKERR  60
   61 K

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle