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Protein Overview: RIB2

General Information:
Name(s) found: RIB2 / YOL066C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 591 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article][IMPLink to PubMed article]
    Biological Process: tRNA pseudouridine synthesis [IDALink to PubMed article][IMPLink to PubMed article]
    riboflavin biosynthetic process [IMPLink to PubMed article]
    Molecular Function: DRAP deaminase activity [IGILink to PubMed article][IMPLink to PubMed article]
    pseudouridylate synthase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDSNNEASD DFNNLLNKEI ESAKEVKLRK FANRNNNRNE NSSKVKDASG FRLRVIQTDG  60
   61 HKTKKTDPDY EVTIDGPLRK IEPYFFTYKT FCKERWRDRK LVDVFVSEFR DREPSYYSKT 120
  121 IAEGKVYLND EPANLDTIIR DGDLITHKVH RHEPPVTSKP IDIVFEDEDI LVIDKPSSIP 180
  181 VHPTGRYRFN TITKMLERQL GYSVHPCNRL DKPTSGLMFL AKTPLGADRM GDQMKAREVT 240
  241 KEYVARVKGE FPIGIVEVDK PVRSVNPKVA LNAVCEMSDE NAKHAKTVFQ RVSYDGQTSI 300
  301 VKCKPLTGRT HQIRVHLQYL GFPIANDPIY SNPDIWGPDL GRGGLQNYDD IVLKLDAIGK 360
  361 TNPAESWIHP HSEGEYLLGR QCEECEAEMY TDPGTNDLDL WLHAFRYESL ERNSDTQKPL 420
  421 WSYRTKYPEW ALEPHRRYME MAVKEAGKCG PTKTAFSVGA VLVHGTQVLA TGYSRELPGN 480
  481 THAEQCALIK YSQLHPNCPT IVPMGTVLYT TMEPCSFRLS GNEPCCDRIL ATQGAIGTVF 540
  541 VGVMEPDTFV KNNTSLNKLE SHGVNYIQIP GYEEECTIIA FKGHDNSDDK A

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen GIR2 RIB2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data RIB2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..100] PSI-BLAST 3.221849 Ribosomal protein S4
    2 View Details [101..166] PSI-BLAST 39.154902 Ribosomal small subunit pseudouridine 516 synthase RsuA; Pseudouridine synthase RsuA N-terminal domain
    3 View Details [167..368] PSI-BLAST 39.154902 Ribosomal small subunit pseudouridine 516 synthase RsuA; Pseudouridine synthase RsuA N-terminal domain
    4 View Details [369..426] deduced N/A No confident structure predictions are available.
    5 View Details [427..591] ORFEUS 11.14 mono-domain cytidine deaminase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • pseudouridine synthase activity
    		•  5.19957135839682 bayes_pls_golite062009
  • intramolecular transferase activity
    		•  3.78688422405974 bayes_pls_golite062009
  • isomerase activity
    		•  2.91720316078381 bayes_pls_golite062009
  • catalytic activity
    		•  2.02180970970004 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.21173188039059 bayes_pls_golite062009
  • DNA binding
    		•  0.950713703876672 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.909704702595901 bayes_pls_golite062009
  • binding
    		•  0.730744558777463 bayes_pls_golite062009
  • RNA binding
    		•  0.706879359688019 bayes_pls_golite062009
  • transferase activity
    		•  0.237728328252954 bayes_pls_golite062009
    3
    Term Confidence Notes
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
    		•  3.83901378721842 bayes_pls_golite062009
  • deaminase activity
    		•  2.68802865527462 bayes_pls_golite062009
  • catalytic activity
    		•  1.70756445127105 bayes_pls_golite062009
  • cyclohydrolase activity
    		•  1.34791174229508 bayes_pls_golite062009
  • methyltransferase activity
    		•  1.24697538679504 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  1.16679252289538 bayes_pls_golite062009
  • binding
    		•  1.05190374148481 bayes_pls_golite062009
  • transferase activity
    		•  0.771056210634777 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle