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Protein Overview: IZH2

General Information:
Name(s) found: IZH2 / YOL002C [SGD]
Description(s) found:
Found 12 descriptions.
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  • Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 327 amino acids

    Gene Ontology:
    Cellular Component: membrane [ISSLink to PubMed article]
    integral to membrane [ISSLink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: response to zinc ion [ISSLink to PubMed article]
    lipid metabolic process [TASLink to PubMed article]
    cellular zinc ion homeostasis [IMPLink to PubMed article][ISSLink to PubMed article]
    response to toxin [IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]
    metal ion binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLHVGEESFQ MSTLLERTKS VQELKKRAAG KTSANPAEVA KAKKVLRRLY SWDEIPEWQR  60
   61 DNDFILHGYV KETSSFIETF KSLFYLHNES VNIYSHLIPA LGFFTVLLLD KSTIKVFATT 120
  121 TWLDHMVIDL FYSGAFACLI LSSSFHCLKS HSLRIATLGN KLDYLGICIL IVTSMVSILY 180
  181 YGYFEKFSLF CLFALITVSF GIACSIVSLK DKFRKREWRP YRAGLFVCFG LSSIIPIFSG 240
  241 LYCYSFSEIW TQIQLFWVLL GGVLYIIGAV LYGMRFPEKI CPGKFDIWGH SHQLFHFLVV 300
  301 IAALCHLRGL LNSYELVHIK MENGIVS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..72] deduced N/A No confident structure predictions are available.
    2 View Details [73..327] Pfam 126.39794 Haemolysin-III related No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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