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Protein Overview: FRE4

General Information:
Name(s) found: FRE4 / YNR060W [SGD]
Description(s) found:
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  • gi|6324388|ref|NP_014458.1| Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels; Fre4p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S63392 probable membrane protein YNR060w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1730689|sp|P53746.1|FRE4_YEAST RecName: Full=Ferric reductase transmembrane component 4; AltName: Full=Ferric-chelate reductase 4; Flags: Precursor [NCBI NR]
  • gi|1302584|emb|CAA96342.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Ferric reductase transmembrane component 4 OS=Saccharomyces cerevisiae GN=FRE4 PE=1 SV=1 [Swiss-Prot]
  • FRE4 Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters [mips]
  • Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels [SGD]
  • (P53746) Ferric reductase transmembrane component 4 precursor (EC 1.16.1.7) (Ferric-chelate reductase 4) [4932.FASTACCERV.txt]
  • Chr XIV from 739946-742105 [hmr_yeast5_DM3-1_pombe.fasta]
  • FRE4, Chr XIV from 739946-742105 [yeast_orfs2]
  • FRE4 SGDID:S0005343, Chr XIV from 739948-742107, Verified ORF [yeastflysequest.fasta]
  • FRE4 SGDID:S0005343, Chr XIV from 739949-742108, Verified ORF [10112005cervSGD.fasta]
  • Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels [Saccharomyces cerevisiae]gi|1302584|emb|CAA96342.1| unnamed protein product [Saccharomyces cerevisiae]gi|173068 [nrdb_11152004_Chlamydomonas]
  • FRE4 SGDID:S000005343, Chr XIV from 739951-742110, Verified ORF, "Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Ferric reductase transmembrane component 4 precursor (Ferric-chelate reductase 4) [nr-271106-contam.fasta]
  • Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels; Fre4p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • FRE4 SGDID:S000005343, Chr XIV from 739952-742111, Verified ORF, "Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels" [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta]
  • [chemostatdb.fasta]
  • Ferric reductase transmembrane component 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FRE4 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • FRE4 SGDID:S000005343, Chr XIV from 739951-742110, Genome Release 64-1-1, Verified ORF, "Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels" [yeast-030211-contam.fasta]
  • Ferric reductase transmembrane component 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FRE4 PE=2 SV=1 [YEAST.fasta.20131015]
  • FRE4 SGDID:S000005343, Chr XIV from 739951-742110, Genome Release 64-2-1, Verified ORF, "Ferric reductase; reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels" [20141208_orf_trans.fasta]
  • YNR060W SGDID:S000005343, Chr XIV from 739951-742110, Genome Release 64-1-1, Verified ORF, "Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 719 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IMPLink to PubMed article][ISSLink to PubMed article]
    Biological Process: siderophore-iron transport [IMPLink to PubMed article]
    Molecular Function: ferric-chelate reductase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLVHIISFL LFFQLSAAKA PPSKTSLINT HERRSIYSCY VGLRKETWGF NGSAICRYEP  60
   61 AIQSMLYCLY EDTHEKGYSN KTLEKGFEEM RQFCYTPKFL NMTDAEFYTS LDNGTYYIQD 120
  121 QPKAGINITY PIRLNTTLRK AYYDAYYGYY YNHDIPYYFG GIICAYFVGV MLLAGLIRFL 180
  181 NYTPIKKIMF QQKLVNYVRG YTTLPTLYEK HAEPFSYLKV ITGYLPTRFE TLVILGYLIL 240
  241 HTIFMAYKYQ YDPYHIIFAA HRAEVAHFVA YRSGILSFAH LPLIVLFAGR NNFLQLISGL 300
  301 KHTSFIVFHK WLGRMMFLDA IIHAAGFTNY YLYYKKWNTV RLRVYWKFGI ATTCLAGMLI 360
  361 FFSIAAFRRH YYETFMALHI VFAALFLYTC WEHVTNFSGI EWIYAAIAIW GVDRIVRITR 420
  421 IALLGFPKAD LQLVGSDLVR VTVKKPKKFW KAKPGQYVFV SFLRPLCFWQ SHPFTVMDSC 480
  481 VNDRELVIVL KAKKGVTKLV RNFVERKGGK ASMRLAIEGP YGSKSTAHRF DNVLLLAGGS 540
  541 GLPGPISHAL ELGKTTAASG KNFVQLVIAV RGLDMLNACK KELMALKGLN VQVHIYNSKQ 600
  601 ELASAEKISS NEVKNGETTA EKAPSSLSNS EKAPSESENT ELPLSLNDTS ISDLEFATFH 660
  661 VGRPNVEEIL NESVNHSGSL AVVCCGPPIF VDTARNQTAK AVIRNPSRMI EYLEEYQAW

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) FET3 FRE1 FRE2 FRE3 FRE4

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..212] MSA 1.05098 View MSA. No confident structure predictions are available.
    2 View Details [213..336] MSA 2.081984 View MSA. Confident ab initio structure predictions are available.
    3 View Details [337..396] deduced N/A No confident structure predictions are available.
    4 View Details [397..521] PSI-BLAST 51.39794 Nitrate reductase core domain; Nitrate reductase
    5 View Details [522..646] PSI-BLAST 51.39794 Nitrate reductase core domain; Nitrate reductase
    6 View Details [647..719] deduced N/A Confident ab initio structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • catalytic activity
    		•  1.45374095556065 bayes_pls_golite062009
  • transferase activity
    		•  1.15480450573972 bayes_pls_golite062009
  • binding
    		•  1.13408475648113 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.27336340260908 bayes_pls_golite062009
  • protein binding
    		•  0.144900113694048 bayes_pls_golite062009
  • cofactor binding
    		•  0.0731141170494622 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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