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Protein Overview: SIP3

General Information:
Name(s) found: SIP3 / YNL257C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Protein that activates transcription through interaction with DNA-bound Snf1p, C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1229 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IPILink to PubMed article]
    Biological Process: transcription initiation from RNA polymerase II promoter [IGILink to PubMed article]
    Molecular Function: transcription cofactor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVHGRDPKK RQLRLISVAF KEASIDSPSF RASVNFFQTR VDALEDWIEK TVDFFDQKYK  60
   61 VSFEDFRRAK ETLLSQLLPP PALLSNGFVS NQSFTPRLID SFNKDYYDFS MKLLQIVKGD 120
  121 DSSHSTALLE LMTTAIEPYR NVRKNFDFYQ GKYDSMLASY QAIRISKTSL EPSSIKSDAL 180
  181 QLFEVQKNYL KASLDLISAI SAVKLSLDKF ILESMKVLKS RSIFITKDSG RKIDLSPCIN 240
  241 EYLDNYAIWV ENSIEGSKVL DSDISNAKKQ AYRYTLKRIT PSSDTSDYNI RSIHSSKLLS 300
  301 KDTQVPPKSP EKSGWLYMKT QVGKPTREIW VRRWCFLKNA VFGMFLLSPS KTYVEETDKF 360
  361 GVFLTNVRYD PEEDRKFCFE VKIFGNKVTE AHDNMSKDIT LVFQTSNYLD LKSWLIAFEA 420
  421 TKKYVMSIQH DSLEYELAFK RFSPKFFEFA SSTTTSIDQL ITTFDKETES LYETLNCSIS 480
  481 EYDILTLGEE KVFQFQMPTT PISTKMTQLA ILSNFLTKGS WFPNAVLANI WGTTDWSEYT 540
  541 ILPGKGKKPS SLLTIDGKRL PIRNSTIYPQ YYSNELKVLD LQFKSLVFSP DQRLEKLPEE 600
  601 LLLFKFEALW CPNKKQKFSA TCFCTKDYIY CYMNSMEFIC LTKISLSEIV SVEADRSSKK 660
  661 TLKLYDASGL QMKAIVLFSD YKLIASKLQY LLENKAIKNP NSNEEILVKF EQMEKESQEK 720
  721 KQEELYKIEQ ENSFDRKATS VSKIIKSRVT FWEMSDDAST LLNRLKKLQT EYSITYNHEY 780
  781 EISSKGLAHI LFGDKSNAFP KCLFLARKDG EEHGKRFWYK NKDINGKSQL VRKIPFRLDM 840
  841 TGNFLNTGKY HRDKESKMIF ATQRIVKIVD NKYYEVDLDP FFVKVPFCHL LKLSIKFVIT 900
  901 ESYDVDNHLE IKLNMTASSS SLHVLYKLEY IDSRTGKTIE KLSLAEIICQ TWALKFAHSE 960
  961 FLLIRRVLRY YLEKIGKHGK VIKAIKLCGI LGVLSNKSEE PATEKNGNSK ESESMQYDIR1020
 1021 YSCTILFLVF IKLMVYRVTN LTFVFFRILI GILLLCAEKF SRINRMMVVG LLASIMINIL1080
 1081 LSEKASVPYW SIKRAEKLFH DRLGSDKFTM QRAIYISDSD LLSSQLSVPS NNPIFEKFSE1140
 1141 DNFNKDYQYS ETRKQLAMRR NELLIELRIL QDMEKQLVHD DYEKFLLEEV NKCSMVSIEM1200
 1201 TDLWFNDTQL QNYCSICNEE LEKLRPPIT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen THO1 SIP3 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SIP3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..162] ORFEUS 8.39 alpha-actinin
    2 View Details [163..295] ORFEUS 8.39 alpha-actinin
    3 View Details [296..414] PSI-BLAST 21.69897 Grp1
    4 View Details [415..544] PSI-BLAST 16.221849 Graf
    5 View Details [545..1229] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • protein binding
    		•  2.87709153890286 bayes_pls_golite062009
  • binding
    		•  2.49469149705983 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.84353598946956 bayes_pls_golite062009
  • transcription activator activity
    		•  1.43685458873431 bayes_pls_golite062009
  • protein complex binding
    		•  0.766875425740451 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.714083718942824 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.702467163177926 bayes_pls_golite062009
  • actin filament binding
    		•  0.519116785342072 bayes_pls_golite062009
  • actin binding
    		•  0.488445831670609 bayes_pls_golite062009
  • identical protein binding
    		•  0.445600866032313 bayes_pls_golite062009
  • receptor binding
    		•  0.194422600694449 bayes_pls_golite062009
    3
    Term Confidence Notes
  • protein binding
    		•  3.17213698546013 bayes_pls_golite062009
  • binding
    		•  2.86147407357315 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.50756932992573 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.2749362891779 bayes_pls_golite062009
  • DNA binding
    		•  1.18878662922624 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.236765394237244 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.198922924806251 bayes_pls_golite062009
    4
    Term Confidence Notes
  • nucleoside-triphosphatase regulator activity
    		•  2.61550569370396 bayes_pls_golite062009
  • GTPase regulator activity
    		•  2.61081671466585 bayes_pls_golite062009
  • enzyme regulator activity
    		•  2.53838406230782 bayes_pls_golite062009
  • GTPase activator activity
    		•  2.52969145422806 bayes_pls_golite062009
  • enzyme activator activity
    		•  2.46273035998947 bayes_pls_golite062009
  • protein binding
    		•  2.26542009538814 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  2.21201833406952 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  2.13452947899012 bayes_pls_golite062009
  • Rho GTPase activator activity
    		•  1.92471602317159 bayes_pls_golite062009
  • binding
    		•  1.83836418355857 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.71759999912525 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.5568815907458 bayes_pls_golite062009
  • DNA binding
    		•  1.36539411736492 bayes_pls_golite062009
  • Rac GTPase activator activity
    		•  0.706062334267926 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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