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Protein Overview: VPS75

General Information:
Name(s) found: VPS75 / YNL246W [SGD]
Description(s) found:
Found 26 descriptions.
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  • NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 264 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    chromatin [IDALink to PubMed article]
    Biological Process: telomere maintenance [IMPLink to PubMed article]
    protein targeting to vacuole [IMPLink to PubMed article]
    nucleosome assembly [IDALink to PubMed article]
    Molecular Function: histone binding [IDALink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMSDQENENE HAKAFLGLAK CEEEVDAIER EVELYRLNKM KPVYEKRDAY IDEIAEFWKI  60
   61 VLSQHVSFAN YIRASDFKYI DTIDKIKVEW LALESEMYDT RDFSITFHFH GIEGDFKEQQ 120
  121 VTKVFQIKKG KDDQEDGILT SEPVPIEWPQ SYDSINPDLI KDKRSPEGKK KYRQGMKTIF 180
  181 GWFRWTGLKP GKEFPHGDSL ASLFSEEIYP FCVKYYAEAQ RDLEDEEGES GLSADGDSED 240
  241 DDGSLGEVDL PLSDEEPSSK KRKV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) RTT109 VPS75
    View Details Krogan NJ, et al. (2006) FMS1 FUS3 RTT109 VPS75

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data VPS75 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..264] Pfam 3.408935 Nucleosome assembly protein (NAP) No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle