Protein Overview: MDG1

General Information:
Name(s) found:	MDG1 / YNL173C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6324156\|ref\|NP_014226.1\| Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations; Mdg1p [Saccharomyces cerevisiae] [NCBI NR] gi\|609652\|gb\|AAA63785.1\| G protein [Saccharomyces cerevisiae] [NCBI NR] gi\|1730804\|sp\|P53885.1\|MDG1_YEAST RecName: Full=Signal transduction protein MDG1; AltName: Full=Multicopy suppressor of defective G-protein 1 [NCBI NR] gi\|1302149\|emb\|CAA96064.1\| MDG1 [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S56040 pheromone response G protein - yeast (Saccharomyces cerevisiae) [NCBI NR] (P53885) Hypothetical 40.3 kDa protein in RPS3-PSD1 intergenic region [Swiss-Prot] Signal transduction protein MDG1 OS=Saccharomyces cerevisiae GN=MDG1 PE=1 SV=1 [Swiss-Prot] MDG1 GTP-binding protein of the pheromone-response pathway [mips] Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations [SGD] MDG1, Chr XIV from 308954-310054, reverse complement [yeast_orfs2] Chr XIV from 308954-310054, reverse complement [yeastorf3.fasta] Chr XIV from 310054-308954, reverse complement [yeastorf5.fasta] MDG1 SGDID:S0005117, Chr XIV from 310057-308957, reverse complement, Verified ORF [yeastflysequest.fasta] Mdg1p [Saccharomyces cerevisiae]gi\|1302149\|emb\|CAA96064.1\| MDG1 [Saccharomyces cerevisiae]gi\|1084544\|pir\|\|S56040 pheromone response G protein - yeast (Saccharomyces cerevisiae)gi\|1730804\|sp\|P53885\|YNR3_YEAST Hypothetical 40.3 kDa protein in RPS3-PSD1 i [nrdb_11152004_Chlamydomonas] MDG1 SGDID:S000005117, Chr XIV from 310059-308959, reverse complement, Verified ORF, "Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations; Mdg1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] MDG1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] G protein [nr-271106-contam.fasta] Signal transduction protein MDG1 (Multicopy suppressor of defective G-protein 1) [nr-271106-contam.fasta] [chemostatdb.fasta] Signal transduction protein MDG1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MDG1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] MDG1 SGDID:S000005117, Chr XIV from 310057-308957, Genome Release 64-1-1, reverse complement, Verified ORF, "Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations" [yeast-030211-contam.fasta] MDG1 SGDID:S000005117, Chr XIV from 310057-308957, Genome Release 64-2-1, reverse complement, Verified ORF, "Plasma membrane protein; involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations; MDG1 has a paralog, CRP1, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YNL173C SGDID:S000005117, Chr XIV from 310057-308957, Genome Release 64-1-1, reverse complement, Verified ORF, "Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	366 amino acids
Gene Ontology:
Cellular Component:	plasma membrane [IDA]
Biological Process:	pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQSSLPQFTF KWPKGPEAII LTGTFDDWKG TLPMVKDPSG AFEITLPVTF DSPSSKFYFK  60
   61 FIVDGQWLPS KDYKVNIDEG VENNFITEED VIKQRENGSS TLVPESAGLA VSKNAPLIEP 120
  121 EAEKRAKKLR KFKIKRVIKT NKQTGERSIF SQEVVELPDS EDETQQVNKT GKNADGLSGT 180
  181 TTIIENNVGV NEEKAIKPYE ENHPKVNLVK SEGYVTDGLG KTQSSESRLY ELSAEDLEKE 240
  241 EEEEDEDKGG GKDTSTSADA EASEDQNKEP LSKSAKFEKP EEKVPVSSIT SHAKETSVKP 300
  301 TGKVATETQT YETKQGAPTA AAKKIEAKKA TRPSKPKGTK ETPNKGVQKN PAKNGGFFKK 360
  361 LAQLLK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	MET18	MDG1	2	Unpublished Fields Lab Data
View Screen	UBC7	MDG1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	MDG1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..366]	ORFEUS	13.44	Sec24

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2