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Protein Overview: ALF1

General Information:
Name(s) found: ALF1 / YNL148C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 254 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: post-chaperonin tubulin folding pathway [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: alpha-tubulin binding [IPILink to PubMed article]
    microtubule binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVRVVIESEL VRTEKELPNS LKLRQFKDRL YHVTGVEPED MEIVVKRQYD NKEIYSTKKG  60
   61 GAYSNEDEDA NFLKGEEELI VVVTDSNAQS ISNQLATQAE GIPSMEVISE EDYLRRDQSV 120
  121 LRWKMAHGYG RFNAAQQSQR AALAKQDEAY AREQLTAAIG RHCRVTVDGS APREAILRYV 180
  181 GPLPLDVMGT WCGVEFPEAA GKNDGRINGV TLFGPVAPGH GSFVRPRAVE ILSKDEESAE 240
  241 VEDVHDDVES DDEI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ALF1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..142] MSA 7.037983 View MSA. No confident structure predictions are available.
    2 View Details [143..254] PSI-BLAST 94.221849 Cytoskeleton-associated protein F53F4.3

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.19381585790185 bayes_pls_golite062009
  • protein binding
    		•  1.17197911794381 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.599634454232833 bayes_pls_golite062009
  • structural molecule activity
    		•  0.576819726104993 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.383121378043805 bayes_pls_golite062009
  • DNA binding
    		•  0.0840213088061073 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.0485636215870291 bayes_pls_golite062009
    2
    Term Confidence Notes
  • tubulin binding
    		•  2.81573953488242 bayes_pls_golite062009
  • microtubule binding
    		•  2.67824962486294 bayes_pls_golite062009
  • binding
    		•  2.07863891614262 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.95334135428526 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  1.16043967945651 bayes_pls_golite062009
  • protein binding
    		•  0.896264971703612 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.625661567957308 bayes_pls_golite062009
  • DNA binding
    		•  0.336599045092266 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.292990934444865 bayes_pls_golite062009
  • catalytic activity
    		•  0.069855517589921 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle