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Protein Overview: PMS1

General Information:
Name(s) found: PMS1 / YNL082W [SGD]
Description(s) found:
Found 15 descriptions.
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  • ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 904 amino acids

    Gene Ontology:
    Cellular Component: nuclear chromosome [TASLink to PubMed article]
    Biological Process: meiotic mismatch repair [IMPLink to PubMed article]
    mismatch repair [TASLink to PubMed article]
    meiosis [TASLink to PubMed article]
    Molecular Function: ATPase activity [IDALink to PubMed article]
    DNA binding [IDALink to PubMed article]
    ATP binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFHHIENLLI ETEKRCKQKE QRYIPVKYLF SMTQIHQIND IDVHRITSGQ VITDLTTAVK  60
   61 ELVDNSIDAN ANQIEIIFKD YGLESIECSD NGDGIDPSNY EFLALKHYTS KIAKFQDVAK 120
  121 VQTLGFRGEA LSSLCGIAKL SVITTTSPPK ADKLEYDMVG HITSKTTTSR NKGTTVLVSQ 180
  181 LFHNLPVRQK EFSKTFKRQF TKCLTVIQGY AIINAAIKFS VWNITPKGKK NLILSTMRNS 240
  241 SMRKNISSVF GAGGMRGLEE VDLVLDLNPF KNRMLGKYTD DPDFLDLDYK IRVKGYISQN 300
  301 SFGCGRNSKD RQFIYVNKRP VEYSTLLKCC NEVYKTFNNV QFPAVFLNLE LPMSLIDVNV 360
  361 TPDKRVILLH NERAVIDIFK TTLSDYYNRQ ELALPKRMCS QSEQQAQKRL KTEVFDDRST 420
  421 THESDNENYH TARSESNQSN HAHFNSTTGV IDKSNGTELT SVMDGNYTNV TDVIGSECEV 480
  481 SVDSSVVLDE GNSSTPTKKL PSIKTDSQNL SDLNLNNFSN PEFQNITSPD KARSLEKVVE 540
  541 EPVYFDIDGE KFQEKAVLSQ ADGLVFVDNE CHEHTNDCCH QERRGSTDTE QDDEADSIYA 600
  601 EIEPVEINVR TPLKNSRKSI SKDNYRSLSD GLTHRKFEDE ILEYNLSTKN FKEISKNGKQ 660
  661 MSSIISKRKS EAQENIIKNK DELEDFEQGE KYLTLTVSKN DFKKMEVVGQ FNLGFIIVTR 720
  721 KVDNKYDLFI VDQHASDEKY NFETLQAVTV FKSQKLIIPQ PVELSVIDEL VVLDNLPVFE 780
  781 KNGFKLKIDE EEEFGSRVKL LSLPTSKQTL FDLGDFNELI HLIKEDGGLR RDNIRCSKIR 840
  841 SMFAMRACRS SIMIGKPLNK KTMTRVVHNL SELDKPWNCP HGRPTMRHLM ELRDWSSFSK 900
  901 DYEI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..249] PSI-BLAST 832.218487 DNA mismatch repair protein PMS2
    2 View Details [250..411] PSI-BLAST 832.218487 DNA mismatch repair protein PMS2
    3 View Details [412..615] PSI-BLAST 2.30103 No description for 1lwzA_ was found.
    4 View Details [616..698] deduced N/A No confident structure predictions are available.
    5 View Details [699..904] MSA 5.021962 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle