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Protein Overview: ERG8

General Information:
Name(s) found: ERG8 / YMR220W [SGD]
Description(s) found:
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  • gi|887601|emb|CAA90191.1| Erg8p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6323876|ref|NP_013947.1| Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate; Erg8p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1706695|sp|P24521.2|ERG8_YEAST RecName: Full=Phosphomevalonate kinase [NCBI NR]
  • pir||S57588 phosphomevalonate kinase (EC 2.7.4.2) - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Phosphomevalonate kinase OS=Saccharomyces cerevisiae GN=ERG8 PE=1 SV=2 [Swiss-Prot]
  • ERG8 Phosphomevalonate kinase [mips]
  • Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate [SGD]
  • ERG8, Chr XIII from 712315-713670 [yeast_orfs2]
  • Chr XIII from 712315-713670 [yeastorf3.fasta]
  • (P24521) Phosphomevalonate kinase (EC 2.7.4.2) [4932.FASTACCERV.txt]
  • ERG8 SGDID:S0004833, Chr XIII from 712315-713670, Verified ORF [yeastflysequest.fasta]
  • Erg8p [Saccharomyces cerevisiae]gi|887601|emb|CAA90191.1| Erg8p [Saccharomyces cerevisiae]gi|1706695|sp|P24521|ERG8_YEAST Phosphomevalonate kinasegi|1362436|pir||S57588 phosphomevalonate kinase (EC 2.7.4.2) - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas]
  • ERG8 SGDID:S000004833, Chr XIII from 712315-713670, Verified ORF, "Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate; Erg8p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Erg8p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Phosphomevalonate kinase [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Phosphomevalonate kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG8 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • ERG8 SGDID:S000004833, Chr XIII from 712316-713671, Genome Release 64-1-1, Verified ORF, "Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate" [yeast-030211-contam.fasta]
  • ERG8 SGDID:S000004833, Chr XIII from 712316-713671, Genome Release 64-2-1, Verified ORF, "Phosphomevalonate kinase; an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate" [20141208_orf_trans.fasta]
  • YMR220W SGDID:S000004833, Chr XIII from 712316-713671, Genome Release 64-1-1, Verified ORF, "Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 451 amino acids

    Gene Ontology:
    Cellular Component: cytosol [TAS]
    Biological Process: ergosterol biosynthetic process [TAS]
    isoprenoid biosynthetic process [TASLink to PubMed article]
    Molecular Function: phosphomevalonate kinase activity [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSELRAFSAP GKALLAGGYL VLDTKYEAFV VGLSARMHAV AHPYGSLQGS DKFEVRVKSK  60
   61 QFKDGEWLYH ISPKSGFIPV SIGGSKNPFI EKVIANVFSY FKPNMDDYCN RNLFVIDIFS 120
  121 DDAYHSQEDS VTEHRGNRRL SFHSHRIEEV PKTGLGSSAG LVTVLTTALA SFFVSDLENN 180
  181 VDKYREVIHN LAQVAHCQAQ GKIGSGFDVA AAAYGSIRYR RFPPALISNL PDIGSATYGS 240
  241 KLAHLVDEED WNITIKSNHL PSGLTLWMGD IKNGSETVKL VQKVKNWYDS HMPESLKIYT 300
  301 ELDHANSRFM DGLSKLDRLH ETHDDYSDQI FESLERNDCT CQKYPEITEV RDAVATIRRS 360
  361 FRKITKESGA DIEPPVQTSL LDDCQTLKGV LTCLIPGAGG YDAIAVITKQ DVDLRAQTAN 420
  421 DKRFSKVQWL DVTQADWGVR KEKDPETYLD K

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ERG8 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..11]
    [34..215]
    [436..451]    		 PSI-BLAST 56.69897 Mevalonate kinase
    2 View Details [12..33]
    [216..435]    		 PSI-BLAST 56.69897 Mevalonate kinase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • diphosphomevalonate decarboxylase activity
    		•  2.34245588421319 bayes_pls_golite062009
  • catalytic activity
    		•  0.836142537655721 bayes_pls_golite062009
  • carbohydrate kinase activity
    		•  0.49664490095304 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.369771518688522 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.325699575011026 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.212099606954236 bayes_pls_golite062009
  • structural molecule activity
    		•  2.19428886088058E-4 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.78

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle