YRC Public Data Repository - Protein Structure Prediction

Protein:	ERG8
Organism:	Saccharomyces cerevisiae
Length:	451 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ERG8.

Description	E-value	Query Range	Subject Range
ERG8_YEAST - Phosphomevalonate kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG8 PE=1 SV=2 ERG8 - Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids...	0.0	[1..451]	[1..451]
GAL1_BACSU - Galactokinase OS=Bacillus subtilis (strain 168) GN=galK PE=3 SV=1 gi\|221316111 - gi\|221316111\|ref\|ZP_03597916.1\| galactokinase [Bacillus subtilis subsp. subtilis str. NCIB 3610] GAL1_BACSU - Galactokinase OS=Bacillus subtilis GN=galK PE=3 SV=1 gi\|221321023 - gi\|221321023\|ref\|ZP_03602317.1\| galactokinase [Bacillus subtilis subsp. subtilis str. JH642] gi\|221325307 - gi\|221325307\|ref\|ZP_03606601.1\| galactokinase [Bacillus subtilis subsp. subtilis str. SMY]	5.0E-73	[7..438]	[22..381]
GAL1_CLOPE - Galactokinase OS=Clostridium perfringens GN=galK PE=3 SV=1 GAL1_CLOPE - Galactokinase OS=Clostridium perfringens (strain 13 / Type A) GN=galK PE=3 SV=1	2.0E-72	[6..438]	[21..381]
GAL1_FUSNN - Galactokinase OS=Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532... GAL1_FUSNN - Galactokinase OS=Fusobacterium nucleatum subsp. nucleatum GN=galK PE=3 SV=1	2.0E-70	[7..438]	[22..382]
gi\|205327714, gi... - gi\|205327714\|gb\|EDZ14478.1\| galactokinase [Salmonella enterica subsp. enterica serovar 4,[5],12:i:- ... GAL1_SALTY - Galactokinase OS=Salmonella typhimurium GN=galK PE=3 SV=2 GAL1_SALNS - Galactokinase OS=Salmonella newport (strain SL254) GN=galK PE=3 SV=1 lcl\|NC_016856.1_... - [gene=galK] [protein=galactokinase] [protein_id=YP_005236493.1] [location=complement(838713..839861)... GAL1_SALTY - Galactokinase OS=Salmonella typhimurium GN=galK PE=3 SV=2 GAL1_SALTY - Galactokinase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=galK PE=3 SV=2	8.0E-70	[6..434]	[22..372]
GAL1_SALDC - Galactokinase OS=Salmonella dublin (strain CT_02021853) GN=galK PE=3 SV=1 gi\|200391087, gi... - gi\|200391087\|ref\|ZP_03217698.1\| galactokinase [Salmonella enterica subsp. enterica serovar Virchow s... gi\|204930110, gi... - gi\|204930110\|ref\|ZP_03221131.1\| galactokinase [Salmonella enterica subsp. enterica serovar Javiana s... gi\|29142528, gi\|... - gi\|29142528\|ref\|NP_805870.1\| galactokinase [Salmonella enterica subsp. enterica serovar Typhi str. T... gi\|16759699 - gi\|16759699\|ref\|NP_455316.1\| galactokinase [Salmonella enterica subsp. enterica serovar Typhi str. C... GAL1_SALTI - Galactokinase OS=Salmonella typhi GN=galK PE=3 SV=1 GAL1_SALTI - Galactokinase OS=Salmonella typhi GN=galK PE=3 SV=1 gi\|238913334 - gi\|238913334\|ref\|ZP_04657171.1\| galactokinase [Salmonella enterica subsp. enterica serovar Tennessee... gi\|214001892 - gi\|214001892\|ref\|ZP_03412627.1\| galactokinase [Salmonella enterica subsp. enterica serovar Typhi str... GAL1_SALEP - Galactokinase OS=Salmonella enteritidis PT4 (strain P125109) GN=galK PE=3 SV=1 gi\|213023145 - gi\|213023145\|ref\|ZP_03337592.1\| galactokinase [Salmonella enterica subsp. enterica serovar Typhi str... gi\|213427697 - gi\|213427697\|ref\|ZP_03360447.1\| galactokinase [Salmonella enterica subsp. enterica serovar Typhi str... gi\|213613330 - gi\|213613330\|ref\|ZP_03371156.1\| galactokinase [Salmonella enterica subsp. enterica serovar Typhi str...	8.0E-70	[6..434]	[22..372]
gi\|251806465, gi... - gi\|251810014\|ref\|ZP_04824487.1\| phosphomevalonate kinase [Staphylococcus epidermidis BCM-HMP0060], g... gi\|242234628, gi... - gi\|242241931\|ref\|ZP_04796376.1\| phosphomevalonate kinase [Staphylococcus epidermidis W23144], gi\|242... gi\|27467281, gi\|... - gi\|27467281\|ref\|NP_763918.1\| phosphomevalonate kinase [Staphylococcus epidermidis ATCC 12228], gi\|27... gi\|9937381 - gi\|9937381\|gb\|AAG02437.1\|AF290091_3 phosphomevalonate kinase [Staphylococcus epidermidis] gi\|57636847, gi\|... - gi\|57866189\|ref\|YP_187836.1\| phosphomevalonate kinase [Staphylococcus epidermidis RP62A], gi\|5763684...	9.0E-70	[4..435]	[1..355]
gi\|227852264, gi... - gi\|227899412\|ref\|ZP_04017217.1\| phosphomevalonate kinase [Staphylococcus aureus subsp. aureus TCH60]... gi\|253316615 - gi\|253316615\|ref\|ZP_04839828.1\| phosphomevalonate kinase [Staphylococcus aureus subsp. aureus str. C... gi\|253724944, gi... - gi\|253731203\|ref\|ZP_04865368.1\| phosphomevalonate kinase [Staphylococcus aureus subsp. aureus USA300... gi\|253729149, gi... - gi\|253732969\|ref\|ZP_04867134.1\| phosphomevalonate kinase [Staphylococcus aureus subsp. aureus TCH130... gi\|255005385 - gi\|255005385\|ref\|ZP_05143986.2\| phosphomevalonate kinase [Staphylococcus aureus subsp. aureus Mu50-o... gi\|90582684, gi\|... - gi\|90582684\|ref\|ZP_01238447.1\| Gram positive phosphomevalonate kinase [Staphylococcus aureus subsp. ... gi\|147740121, gi... - gi\|90585396\|ref\|ZP_01241106.1\| Gram positive phosphomevalonate kinase [Staphylococcus aureus subsp. ... gi\|269202214\|ref... - phosphomevalonate kinase [Staphylococcus aureus subsp. aureus ED98] gi\|25379789 - pir\|\|B89828 phosphomevalonate kinase [imported] - Staphylococcus aureus (strain N315) gi\|156721056, gi... - gi\|156978921\|ref\|YP_001441180.1\| phosphomevalonate kinase [Staphylococcus aureus subsp. aureus Mu3],... gi\|49240951, gi\|... - gi\|49482822\|ref\|YP_040046.1\| phosphomevalonate kinase [Staphylococcus aureus subsp. aureus MRSA252],... gi\|82655828, gi\|... - gi\|82750297\|ref\|YP_416038.1\| phosphomevalonate kinase [Staphylococcus aureus RF122], gi\|82655828\|emb... gi\|151220767, gi... - gi\|151220767\|ref\|YP_001331589.1\| phosphomevalonate kinase [Staphylococcus aureus subsp. aureus str. ... gi\|221141882 - gi\|221141882\|ref\|ZP_03566375.1\| phosphomevalonate kinase [Staphylococcus aureus subsp. aureus str. J... gi\|221139201 - gi\|221139201\|ref\|ZP_03564001.1\| phosphomevalonate kinase [Staphylococcus aureus subsp. aureus str. J... gi\|14246360, gi\|... - gi\|15923582\|ref\|NP_371116.1\| phosphomevalonate kinase [Staphylococcus aureus subsp. aureus Mu50], gi... gi\|87201911, gi\|... - gi\|88194353\|ref\|YP_499146.1\| phosphomevalonate kinase [Staphylococcus aureus subsp. aureus NCTC 8325... gi\|13700484, gi\|... - gi\|15926270\|ref\|NP_373803.1\| phosphomevalonate kinase [Staphylococcus aureus subsp. aureus N315], gi... gi\|57650049, gi\|... - gi\|57650049\|ref\|YP_185523.1\| phosphomevalonate kinase [Staphylococcus aureus subsp. aureus COL], gi\|... gi\|227557353, gi... - gi\|227557353\|ref\|ZP_03987400.1\| phosphomevalonate kinase [Staphylococcus aureus subsp. aureus MN8], ...	1.0E-69	[4..435]	[1..355]
gi\|9937374 - gi\|9937374\|gb\|AAG02432.1\|AF290089_3 phosphomevalonate kinase [Staphylococcus haemolyticus]	2.0E-69	[4..435]	[1..355]

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Predicted Domain #1

Region A:
Residues: [1-11]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSELRAFSAP G

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [34-215]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SARMHAVAHP YGSLQGSDKF EVRVKSKQFK DGEWLYHISP KSGFIPVSIG GSKNPFIEKV  60
   61 IANVFSYFKP NMDDYCNRNL FVIDIFSDDA YHSQEDSVTE HRGNRRLSFH SHRIEEVPKT 120
  121 GLGSSAGLVT VLTTALASFF VSDLENNVDK YREVIHNLAQ VAHCQAQGKI GSGFDVAAAA 180
  181 YG

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [436-451]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DWGVRKEKDP ETYLDK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	56.69897
Match:	1kvkA_
Description:	Mevalonate kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
diphosphomevalonate decarboxylase activity	2.34245588421319	bayes_pls_golite062009
catalytic activity	0.836142537655721	bayes_pls_golite062009
carbohydrate kinase activity	0.49664490095304	bayes_pls_golite062009
nucleic acid binding	0.369771518688522	bayes_pls_golite062009
structural constituent of ribosome	0.325699575011026	bayes_pls_golite062009
transcription regulator activity	0.212099606954236	bayes_pls_golite062009
structural molecule activity	2.19428886088058E-4	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [12-33]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KALLAGGYLV LDTKYEAFVV GL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [216-435]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SIRYRRFPPA LISNLPDIGS ATYGSKLAHL VDEEDWNITI KSNHLPSGLT LWMGDIKNGS  60
   61 ETVKLVQKVK NWYDSHMPES LKIYTELDHA NSRFMDGLSK LDRLHETHDD YSDQIFESLE 120
  121 RNDCTCQKYP EITEVRDAVA TIRRSFRKIT KESGADIEPP VQTSLLDDCQ TLKGVLTCLI 180
  181 PGAGGYDAIA VITKQDVDLR AQTANDKRFS KVQWLDVTQA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	56.69897
Match:	1kvkA_
Description:	Mevalonate kinase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: