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Protein Overview: MOT3

General Information:
Name(s) found: MOT3 / YMR070W [SGD]
Description(s) found:
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  • gi|805130|gb|AAC49982.1| Mot3p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|763017|emb|CAA88795.1| unknown [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6323715|ref|NP_013786.1| Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic ge [NCBI NR]
  • gi|51013869|gb|AAT93228.1| YMR070W [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1708268|sp|P54785.1|MOT3_YEAST RecName: Full=Transcriptional activator/repressor MOT3; AltName: Full=Modulator of transcription protein 3; AltName: Full=Hypoxic gene repressor protein 7 [NCBI NR]
  • pir||S52830 HMS1 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Transcriptional activator/repressor MOT3 OS=Saccharomyces cerevisiae GN=MOT3 PE=1 SV=1 [Swiss-Prot]
  • MOT3 High-copy suppressor of MOT1-SPT3 synthetic lethality [mips]
  • Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes [SGD]
  • MOT3, Chr XIII from 409153-410625 [yeast_orfs2]
  • Chr XIII from 409153-410625 [yeastorf3.fasta]
  • (P54785) Zinc finger protein MOT3/HMS1 [4932.FASTACCERV.txt]
  • MOT3 SGDID:S0004674, Chr XIII from 409153-410625, Verified ORF [yeastflysequest.fasta]
  • Mot3p [Saccharomyces cerevisiae]gi|51013869|gb|AAT93228.1| YMR070W [Saccharomyces cerevisiae]gi|763017|emb|CAA88795.1| unknown [Saccharomyces cerevisiae]gi|1708268|sp|P54785|MOT3_YEAST Zinc finger protein MOT3/HMS1gi|805130|gb|AAC49982.1| Mot3p [Sacch [nrdb_11152004_Chlamydomonas]
  • MOT3 SGDID:S000004674, Chr XIII from 409153-410625, Verified ORF, "Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and r [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • YMR070W [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Mot3p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes; Mot3p [Saccharomyces ce [nr-271106-contam.fasta]
  • Transcriptional activator/repressor MOT3 (Modulator of transcription protein 3) (Hypoxic gene repressor protein 7) [nr-271106-contam.fasta]
  • MOT3 SGDID:S000004674, Chr XIII from 409153-410625, Verified ORF, "Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Transcriptional activator/repressor MOT3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MOT3 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • MOT3 SGDID:S000004674, Chr XIII from 409154-410626, Genome Release 64-1-1, Verified ORF, "Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes; can form the [MOT3+] prion" [yeast-030211-contam.fasta]
  • MOT3 SGDID:S000004674, Chr XIII from 409154-410626, Genome Release 64-2-1, Verified ORF, "Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth and ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; relocalizes to the cytosol in response to hypoxia; can form [MOT3+] prion" [20141208_orf_trans.fasta]
  • YMR070W SGDID:S000004674, Chr XIII from 409154-410626, Genome Release 64-1-1, Verified ORF, "Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes; can form the [MOT3+] prion" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 490 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    Biological Process: transcription [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    telomere maintenance [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: DNA binding [IPILink to PubMed article]
    transcription activator activity [TASLink to PubMed article]
    transcription repressor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNADHHLQQQ QQQRQQHQQQ QHQQQQHQHQ HQQQQHTILQ NVSNTNNIGS DSLASQPFNT  60
   61 TTVSSNKDDV MVNSGARELP MPLHQQQYIY PYYQYTSNNS NNNNVTAGNN MSASPIVHNN 120
  121 SNNSNNSNIS ASDYTVANNS TSNNNNNNNN NNNNNNNIHP NQFTAAANMN SNAAAAAYYS 180
  181 FPTANMPIPQ QDQQYMFNPA SYISHYYSAV NSNNNGNNAA NNGSNNSSHS APAPAPGPPH 240
  241 HHHHHSNTHN NLNNGGAVNT NNAPQHHPTI ITDQFQFQLQ QNPSPNLNLN INPAQPLHLP 300
  301 PGWKINTMPQ PRPTTAPNHP PAPVPSSNPV ASNLVPAPSS DHKYIHQCQF CEKSFKRKSW 360
  361 LKRHLLSHSQ QRHFLCPWCL SRQKRKDNLL QHMKLKHTNY LLDELKKNNI IFNYNNSSSS 420
  421 NNNNDNNNNN NSNSASGSGG AGAAAAAATA PENEDGNGYD TNIKTLINDG VLNKDDVKRV 480
  481 LNNLIVSHNK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MOT3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..164] deduced N/A No confident structure predictions are available.
    2 View Details [165..282] MSA 50.144997 View MSA. No confident structure predictions are available.
    3 View Details [283..367] PSI-BLAST 43.264245 No description for 1lu6A_ was found.
    4 View Details [368..490] PSI-BLAST 43.264245 No description for 1lu6A_ was found.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle