Protein Overview: YLR446W

General Information:
Name(s) found:	YLR446W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|74644950\|sp\|Q06204.1\|YL446_YEAST RecName: Full=Putative hexokinase YLR446W [NCBI NR] gi\|717064\|gb\|AAB67530.1\| Ylr446wp [Saccharomyces cerevisiae] [NCBI NR] gi\|6323479\|ref\|NP_013551.1\| Putative protein of unknown function with similarity to hexokinases; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene; Ylr446wp [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S55968 probable membrane protein YLR446w - yeast (Saccharomyces cerevisiae) [NCBI NR] Putative hexokinase YLR446W OS=Saccharomyces cerevisiae GN=YLR446W PE=1 SV=1 [Swiss-Prot] Weak similarity to hexokinases [mips] Putative protein of unknown function with similarity to hexokinases; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene [SGD] YLR446W, Chr XII from 1025209-1026510 [yeast_orfs2] Chr XII from 1025209-1026510 [yeastorf3.fasta] >Q06204 (Q06204) Similar in the center of the protein to hexokinase type I from human [4932.FASTACCERV.txt] YLR446W SGDID:S0004438, Chr XII from 1025210-1026511, Uncharacterized ORF [yeastflysequest.fasta] Ylr446wp [Saccharomyces cerevisiae]gi\|1084657\|pir\|\|S55968 probable membrane protein YLR446w - yeast (Saccharomyces cerevisiae)gi\|717064\|gb\|AAB67530.1\| Ylr446wp [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas] (Q06204) Ylr446wp [cerv4932.FASTAC] YLR446W SGDID:S000004438, Chr XII from 1025210-1026511, Uncharacterized ORF, "Hypothetical protein" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] YLR446W SGDID:S000004438, Chr XII from 1025211-1026512, Uncharacterized ORF, "Putative protein of unknown function with similarity to hexokinases; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential [yeast-contam.fasta] Ylr446wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Putative protein of unknown function with similarity to hexokinases; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene; Ylr446wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta] YLR446W SGDID:S000004438, Chr XII from 1025211-1026512, Uncharacterized ORF, "Putative protein of unknown function with similarity to hexokinases; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Putative hexokinase YLR446W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YLR446W PE=2 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] YLR446W SGDID:S000004438, Chr XII from 1025214-1026515, Genome Release 64-1-1, Uncharacterized ORF, "Putative protein of unknown function with similarity to hexokinases; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene" [yeast-030211-contam.fasta] Putative hexokinase YLR446W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YLR446W PE=3 SV=1 [YEAST.fasta.20131015] YLR446W SGDID:S000004438, Chr XII from 1025214-1026515, Genome Release 64-2-1, Uncharacterized ORF, "Putative hexokinase; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene" [20141208_orf_trans.fasta]
Organism:	Saccharomyces cerevisiae
Length:	433 amino acids
Gene Ontology:
Cellular Component:	cellular_component [ND]
Biological Process:	biological_process [ND]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTIESTLARE LESLILPADS IVNVVDQFQE ELLSRLQTNT ISMLPQCLVP DKRSRWNPED  60
   61 KILTIDFGGT RLKFAIISLP QIVIEYNDAF ELTYNIVDSN FFNQIIYTIC TRLAANGYIK 120
  121 KKNESSEASK FFVSVTFSFP LNPEGEVVAM GKGFVMTDTL QGSTVKQLIQ SSFHRIISEN 180
  181 IEEFFCTMNV CHVINDAIAV SLTSKFICEN DSISLIIGTG TNACFEVPYG YLPPFKRDAL 240
  241 RETLPSSYNK ETLNFKHVLI NSEIGFIGKN VIALQPFDIH GAISYEMPLE CVTSGKWLPL 300
  301 SLKNILLQYN IIPKNFPVEF NGELVCQLAE DCTNAWFENE HYALICQIAR LLIKRAAFYV 360
  361 AAIVQAIDII TGCKNYNFIH IGYVGSFLHN SNFYREQIKY YSSIHIKLQF LNHSNLLGAA 420
  421 IATYLNKSDN QVQ

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	PRP16	YLR446W	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..433]	PSI-BLAST	216.0	Mammalian type I hexokinase

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
catalytic activity	0.296484721581333	bayes_pls_golite062009
carbohydrate kinase activity	0.127155756785582	bayes_pls_golite062009
binding	0.067254720556817	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.96

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2