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Protein Overview: FRE1

General Information:
Name(s) found: FRE1 / YLR214W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 686 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDALink to PubMed article]
    Biological Process: iron ion transport [IDALink to PubMed article]
    copper ion import [IDALink to PubMed article]
    Molecular Function: ferric-chelate reductase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVRTRVLFCL FISFFATVQS SATLISTSCI SQAALYQFGC SSKSKSCYCK NINWLGSVTA  60
   61 CAYENSKSNK TLDSALMKLA SQCSSIKVYT LEDMKNIYLN ASNYLRAPEK SDKKTVVSQP 120
  121 LMANETAYHY YYEENYGIHL NLMRSQWCAW GLVFFWVAVL TAATILNILK RVFGKNIMAN 180
  181 SVKKSLIYPS VYKDYNERTF YLWKRLPFNF TTRGKGLVVL IFVILTILSL SFGHNIKLPH 240
  241 PYDRPRWRRS MAFVSRRADL MAIALFPVVY LFGIRNNPFI PITGLSFSTF NFYHKWSAYV 300
  301 CFMLAVVHSI VMTASGVKRG VFQSLVRKFY FRWGIVATIL MSIIIFQSEK VFRNRGYEIF 360
  361 LLIHKAMNIM FIIAMYYHCH TLGWMGWIWS MAGILCFDRF CRIVRIIMNG GLKTATLSTT 420
  421 DDSNVIKISV KKPKFFKYQV GAFAYMYFLS PKSAWFYSFQ SHPFTVLSER HRDPNNPDQL 480
  481 TMYVKANKGI TRVLLSKVLS APNHTVDCKI FLEGPYGVTV PHIAKLKRNL VGVAAGLGVA 540
  541 AIYPHFVECL RLPSTDQLQH KFYWIVNDLS HLKWFENELQ WLKEKSCEVS VIYTGSSVED 600
  601 TNSDESTKGF DDKEESEITV ECLNKRPDLK ELVRSEIKLS ELENNNITFY SCGPATFNDD 660
  661 FRNAVVQGID SSLKIDVELE EESFTW

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) FET3 FRE1 FRE2 FRE3 FRE4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #21 Asynchronous Prep2-IMAC Phosphopeptide enrichment A1 Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..144] deduced N/A No confident structure predictions are available.
    2 View Details [145..331] MSA 2.076988 View MSA. No confident structure predictions are available.
    3 View Details [332..386] deduced N/A No confident structure predictions are available.
    4 View Details [387..516] PSI-BLAST 52.69897 Nitrate reductase core domain; Nitrate reductase
    5 View Details [517..686] PSI-BLAST 52.69897 Nitrate reductase core domain; Nitrate reductase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • catalytic activity
    		•  1.45374095556065 bayes_pls_golite062009
  • transferase activity
    		•  1.15480450573972 bayes_pls_golite062009
  • binding
    		•  1.13408475648113 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.27336340260908 bayes_pls_golite062009
  • protein binding
    		•  0.144900113694048 bayes_pls_golite062009
  • cofactor binding
    		•  0.0731141170494622 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle