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Protein Overview: ERG3

General Information:
Name(s) found: ERG3 / YLR056W [SGD]
Description(s) found:
Found 33 descriptions.
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  • C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 365 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [TAS]
    Biological Process: ergosterol biosynthetic process [TAS]
    endocytosis [IGILink to PubMed article]
    Molecular Function: C-5 sterol desaturase activity [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLVLEVADH YVLDDLYAKV LPASLAANIP VKWQKLLGLN SGFSNSTILQ ETLNSKNAVK  60
   61 ECRRFYGQVP FLFDMSTTSF ASLLPRSSIL REFLSLWVIV TIFGLLLYLF TASLSYVFVF 120
  121 DKSIFNHPRY LKNQMAMEIK LAVSAIPWMS MLTVPWFVME LNGHSKLYMK IDYENHGVRK 180
  181 LIIEYFTFIF FTDCGVYLAH RWLHWPRVYR ALHKPHHKWL VCTPFASHSF HPVDGFLQSI 240
  241 SYHIYPLILP LHKVSYLILF TFVNFWTVMI HDGQYLSNNP AVNGTACHTV HHLYFNYNYG 300
  301 QFTTLWDRLG GSYRRPDDSL FDPKLRDAKE TWDAQVKEVE HFIKEVEGDD NDRIYENDPN 360
  361 TKKNN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ERG24 ERG3

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ERG3 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..84] deduced N/A No confident structure predictions are available.
    2 View Details [85..365] Pfam 81.958607 Sterol desaturase No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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