YRC Public Data Repository - Protein Structure Prediction

Protein:	ERG3
Organism:	Saccharomyces cerevisiae
Length:	365 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ERG3.

Description	E-value	Query Range	Subject Range
ERG3 - C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precurso... ERG3_YEAST - Delta(7)-sterol 5(6)-desaturase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG3 PE=...	0.0	[1..365]	[1..365]
ERG3_CANGA - Delta(7)-sterol 5(6)-desaturase OS=Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 06... ERG3_CANGA - C-5 sterol desaturase OS=Candida glabrata GN=ERG3 PE=3 SV=1	5.0E-96	[1..365]	[1..364]
ERG3_CANAX - Delta(7)-sterol 5(6)-desaturase OS=Candida albicans GN=ERG3 PE=3 SV=1 gi\|238879059 - gi\|238879059\|gb\|EEQ42697.1\| C-5 sterol desaturase [Candida albicans WO-1]	2.0E-86	[1..355]	[1..383]
SPBC27B12.03c - lathosterol oxidase ERG32_SCHPO - Delta(7)-sterol 5(6)-desaturase erg32 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=erg3...	2.0E-63	[1..365]	[1..329]
erg3 - C-5 sterol desaturase Erg3 ERG31_SCHPO - Delta(7)-sterol 5(6)-desaturase erg31 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=erg3...	1.0E-61	[84..365]	[23..300]
gi\|74178504, gi\|... - gi\|74178504\|dbj\|BAE32506.1\| unnamed protein product [Mus musculus], gi\|18848246\|gb\|AAH24132.1\| Stero...	3.0E-58	[58..330]	[3..271]
SC5D_RAT - Lathosterol oxidase OS=Rattus norvegicus GN=Sc5d PE=1 SV=1	4.0E-57	[58..330]	[3..271]

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Predicted Domain #1

Region A:
Residues: [1-84]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLVLEVADH YVLDDLYAKV LPASLAANIP VKWQKLLGLN SGFSNSTILQ ETLNSKNAVK  60
   61 ECRRFYGQVP FLFDMSTTSF ASLL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [85-365]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRSSILREFL SLWVIVTIFG LLLYLFTASL SYVFVFDKSI FNHPRYLKNQ MAMEIKLAVS  60
   61 AIPWMSMLTV PWFVMELNGH SKLYMKIDYE NHGVRKLIIE YFTFIFFTDC GVYLAHRWLH 120
  121 WPRVYRALHK PHHKWLVCTP FASHSFHPVD GFLQSISYHI YPLILPLHKV SYLILFTFVN 180
  181 FWTVMIHDGQ YLSNNPAVNG TACHTVHHLY FNYNYGQFTT LWDRLGGSYR RPDDSLFDPK 240
  241 LRDAKETWDA QVKEVEHFIK EVEGDDNDRI YENDPNTKKN N

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	81.958607
Match:	PF01598
Description:	Sterol desaturase

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits