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Protein Overview: THI73

General Information:
Name(s) found: THI73 / YLR004C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 523 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [ISSLink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: transport [ISSLink to PubMed article]
    Molecular Function: transporter activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNMSQRSMD VEKKAANADS CSVSTSSINV DDADVALRFL KQNGLDESST ANEDDVVAGE  60
   61 EANFYGSHEL SPKVLRKVDL FILPFLCCTY LLMFLDKALL NYAASMGIKD HLKGNEFSNL 120
  121 GTIFSAAYIF MEPVVTYLIQ KFPISKILGT FITVWGIVLA CHAACKTYAS LMVVRTLLGL 180
  181 FESSSAVGCI AISGMYYTKS EQSARIGFWA TQAGTGYIVG GLISFGFLHY HGTAFTSWQI 240
  241 MFLVVGLVTV AFGVLTFLYL PDNVTNAWFL NKEEKIQVVE HIRANQTGLE TKKFKKQQVK 300
  301 ELFLHDKFTW PMLLLTACSQ ISTGAIGTFS VTITGTFGFD KYETALLQLP IGAITAMIIL 360
  361 ITTQMLSRWG HITLITTSMY IPAIIGCIVL ISLPLSHKIG NLFSLYLLYS GSCVITNIYI 420
  421 WNSCNTSGYT KRVFRNAITM IVYNVSCIIA PQMFRAYSAP RYIPAKIALL VTQCVCVPLQ 480
  481 LYIGYICKKE NEKRDKEQEG QERKKYQFLD LTDIENRNFR YIY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..523] PSI-BLAST 46.522879 No description for 1ja5A_ was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • substrate-specific transmembrane transporter activity
    		•  5.46247398538901 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  4.58978526526921 bayes_pls_golite062009
  • transporter activity
    		•  4.09176719149278 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  3.94605227012838 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  3.88180006470231 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.59744164024479 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.5865018981083 bayes_pls_golite062009
  • inorganic anion transmembrane transporter activity
    		•  2.52916479889426 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  2.15783210522667 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.59419818573076 bayes_pls_golite062009
  • secondary active transmembrane transporter activity
    		•  1.22264637452409 bayes_pls_golite062009
  • polyol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • alcohol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • binding
    		•  0.873217664940684 bayes_pls_golite062009
  • glycerol transmembrane transporter activity
    		•  0.812001619402678 bayes_pls_golite062009
  • symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • solute:cation symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • phosphate transmembrane transporter activity
    		•  0.312628600969375 bayes_pls_golite062009
  • cation:sugar symporter activity
    		•  0.143419068761182 bayes_pls_golite062009
  • sugar:hydrogen symporter activity
    		•  0.143419068761182 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle