YRC Public Data Repository - Protein Structure Prediction

Protein:	THI73
Organism:	Saccharomyces cerevisiae
Length:	523 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for THI73.

Description	E-value	Query Range	Subject Range
THI73_YEAST - Thiamine pathway transporter THI73 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=THI73... gi\|151941172 - gi\|151941172\|gb\|EDN59550.1\| THI regulon [Saccharomyces cerevisiae YJM789] gi\|190406045 - gi\|190406045\|gb\|EDV09312.1\| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a] THI73 - Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by...	8.0E-80	[1..523]	[1..523]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	6.0E-78	[69..501]	[13..487]
STP1_ARATH - Sugar transport protein 1 OS=Arabidopsis thaliana GN=STP1 PE=1 SV=2	2.0E-77	[68..501]	[12..487]
STC_RICCO - Sugar carrier protein C OS=Ricinus communis GN=STC PE=2 SV=1	4.0E-77	[78..501]	[24..489]
KHT2_KLULC - Hexose transporter 2 OS=Kluyveromyces lactis GN=KHT2 PE=3 SV=1	1.0E-76	[34..505]	[14..529]
gi\|115470211, gi... - gi\|50508995\|dbj\|BAD31944.1\| putative monosaccharide transport protein MST1 [Oryza sativa Japonica Gr... gi\|125556956 - gi\|125556956\|gb\|EAZ02492.1\| hypothetical protein OsI_24597 [Oryza sativa Indica Group] gi\|11991114 - gi\|11991114\|dbj\|BAB19864.1\| monosaccharide transporter 3 [Oryza sativa]	3.0E-76	[72..499]	[16..485]
gi\|16080636, gi\|... - gi\|2636109\|emb\|CAB15600.1\| ywtG [Bacillus subtilis subsp. subtilis str. 168], gi\|16080636\|ref\|NP_391... gi\|7446721, gi\|1... - pir\|\|E70070 metabolite transport protein homolog ywtG - Bacillus subtilis, gi\|1894771\|emb\|CAB07473.1...	1.0E-75	[80..507]	[7..443]

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Predicted Domain #1

Region A:
Residues: [1-523]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNMSQRSMD VEKKAANADS CSVSTSSINV DDADVALRFL KQNGLDESST ANEDDVVAGE  60
   61 EANFYGSHEL SPKVLRKVDL FILPFLCCTY LLMFLDKALL NYAASMGIKD HLKGNEFSNL 120
  121 GTIFSAAYIF MEPVVTYLIQ KFPISKILGT FITVWGIVLA CHAACKTYAS LMVVRTLLGL 180
  181 FESSSAVGCI AISGMYYTKS EQSARIGFWA TQAGTGYIVG GLISFGFLHY HGTAFTSWQI 240
  241 MFLVVGLVTV AFGVLTFLYL PDNVTNAWFL NKEEKIQVVE HIRANQTGLE TKKFKKQQVK 300
  301 ELFLHDKFTW PMLLLTACSQ ISTGAIGTFS VTITGTFGFD KYETALLQLP IGAITAMIIL 360
  361 ITTQMLSRWG HITLITTSMY IPAIIGCIVL ISLPLSHKIG NLFSLYLLYS GSCVITNIYI 420
  421 WNSCNTSGYT KRVFRNAITM IVYNVSCIIA PQMFRAYSAP RYIPAKIALL VTQCVCVPLQ 480
  481 LYIGYICKKE NEKRDKEQEG QERKKYQFLD LTDIENRNFR YIY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	46.522879
Match:	1ja5A_
Description:	No description for 1ja5A_ was found.

Predicted functions:

Term	Confidence	Notes
substrate-specific transmembrane transporter activity	5.46247398538901	bayes_pls_golite062009
ion transmembrane transporter activity	4.58978526526921	bayes_pls_golite062009
transporter activity	4.09176719149278	bayes_pls_golite062009
anion transmembrane transporter activity	3.94605227012838	bayes_pls_golite062009
cation transmembrane transporter activity	3.88180006470231	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	2.52916479889426	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.15783210522667	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
binding	0.873217664940684	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
phosphate transmembrane transporter activity	0.312628600969375	bayes_pls_golite062009
cation:sugar symporter activity	0.143419068761182	bayes_pls_golite062009
sugar:hydrogen symporter activity	0.143419068761182	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: