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Protein Overview: PTR2

General Information:
Name(s) found: PTR2 / YKR093W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 601 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDALink to PubMed article][IMPLink to PubMed article]
    Biological Process: dipeptide transport [IDALink to PubMed article]
    tripeptide transport [IDALink to PubMed article]
    peptide transport [IMPLink to PubMed article]
    Molecular Function: dipeptide transporter activity [IDALink to PubMed article]
    tripeptide transporter activity [IDALink to PubMed article]
    peptide transporter activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLNHPSQGSD DAQDEKQGDF PVIEEEKTQA VTLKDSYVSD DVANSTERYN LSPSPEDEDF  60
   61 EGPTEEEMQT LRHVGGKIPM RCWLIAIVEL SERFSYYGLS APFQNYMEYG PNDSPKGVLS 120
  121 LNSQGATGLS YFFQFWCYVT PVFGGYVADT FWGKYNTICC GTAIYIAGIF ILFITSIPSV 180
  181 GNRDSAIGGF IAAIILIGIA TGMIKANLSV LIADQLPKRK PSIKVLKSGE RVIVDSNITL 240
  241 QNVFMFFYFM INVGSLSLMA TTELEYHKGF WAAYLLPFCF FWIAVVTLIF GKKQYIQRPI 300
  301 GDKVIAKSFK VCWILTKNKF DFNAAKPSVH PEKNYPWNDK FVDEIKRALA ACKVFIFYPI 360
  361 YWTQYGTMIS SFITQASMME LHGIPNDFLQ AFDSIALIIF IPIFEKFVYP FIRRYTPLKP 420
  421 ITKIFFGFMF GSFAMTWAAV LQSFVYKAGP WYNEPLGHNT PNHVHVCWQI PAYVLISFSE 480
  481 IFASITGLEY AYSKAPASMK SFIMSIFLLT NAFGSAIGCA LSPVTVDPKF TWLFTGLAVA 540
  541 CFISGCLFWL CFRKYNDTEE EMNAMDYEEE DEFDLNPISA PKANDIEILE PMESLRSTTK 600
  601 Y

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PTR2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..290]
    [335..560]    		 PSI-BLAST 62.69897 No description for 1ja5A_ was found.
    2 View Details [291..334]
    [561..601]    		 PSI-BLAST 62.69897 No description for 1ja5A_ was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transporter activity
    		•  3.82096685159505 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.34396155292818 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.07161916881404 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.00564985710417 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  2.05049771748124 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.75140121218978 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.46819549608723 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.34985844043603 bayes_pls_golite062009
  • secondary active transmembrane transporter activity
    		•  0.869150152038001 bayes_pls_golite062009
  • binding
    		•  0.842346892851231 bayes_pls_golite062009
  • polyol transmembrane transporter activity
    		•  0.339747214378126 bayes_pls_golite062009
  • alcohol transmembrane transporter activity
    		•  0.339747214378126 bayes_pls_golite062009
  • symporter activity
    		•  0.327558013224678 bayes_pls_golite062009
  • solute:cation symporter activity
    		•  0.327558013224678 bayes_pls_golite062009
  • glycerol transmembrane transporter activity
    		•  0.222664452597504 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle