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Protein Overview: TRM2

General Information:
Name(s) found: TRM2 / YKR056W [SGD]
Description(s) found:
Found 12 descriptions.
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  • tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 617 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: DNA repair [IGILink to PubMed article][IMPLink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    tRNA modification [IDALink to PubMed article]
    Molecular Function: double-stranded DNA specific 5'-3' exodeoxyribonuclease activity [IDALink to PubMed article]
    tRNA (m5U54) methyltransferase activity [IDALink to PubMed article][IMPLink to PubMed article]
    single-stranded DNA specific endodeoxyribonuclease activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYEQFEFSFF FFENSDNKVK YKAHLISSIK RWSIITCMRC FWTVQKSIFK ARFFACRNFV  60
   61 KKHNYKLIST MTGSTEMVPP TMKHTVDNKR LSSPLTDSGN RRTKKPKLRK YKAKKVETTS 120
  121 PMGVLEFEVN DLLKSQNLSR EQVLNDVTSI LNDKSSTDGP IVLQYHREVK NVKVLEITSN 180
  181 GNGLALIDNP VETEKKQVVI IPFGLPGDVV NIKVFKTHPY YVESDLLDVV EKSPMRRDDL 240
  241 IRDKYFGKSS GSQLEFLTYD DQLELKRKTI MNAYKFFAPR LVAEKLLPPF DTTVASPLQF 300
  301 GYRTKITPHF DMPKRKQKEL SVRPPLGFGQ KGRPQWRKDT LDIGGHGSIL DIDECVLATE 360
  361 VLNKGLTNER RKFEQEFKNY KKGATILLRE NTTILDPSKP TLEQLTEEAS RDENGDISYV 420
  421 EVEDKKNNVR LAKTCVTNPR QIVTEYVDGY TFNFSAGEFF QNNNSILPIV TKYVRDNLQA 480
  481 PAKGDDNKTK FLVDAYCGSG LFSICSSKGV DKVIGVEISA DSVSFAEKNA KANGVENCRF 540
  541 IVGKAEKLFE SIDTPSENTS VILDPPRKGC DELFLKQLAA YIQPRLFTYR VMSIPRHVMS 600
  601 STSSKKQKTV PPTRLKA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..156] deduced N/A No confident structure predictions are available.
    2 View Details [157..240] Pfam 13.823909 TRAM domain No confident structure predictions are available.
    3 View Details [241..357] MSA 2.282994 View MSA. No confident structure predictions are available.
    4 View Details [358..431] deduced N/A No confident structure predictions are available.
    5 View Details [432..617] PSI-BLAST 15.045757 Arginine methyltransferase, HMT1


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle