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Protein Overview: MCH2

General Information:
Name(s) found: MCH2 / YKL221W [SGD]
Description(s) found:
Found 21 descriptions.
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  • Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 473 amino acids

    Gene Ontology:
    Cellular Component: membrane [ISSLink to PubMed article]
    Biological Process: transport [ISSLink to PubMed article]
    Molecular Function: transporter activity [ISSLink to PubMed article]
    [NOT]monocarboxylic acid transmembrane transporter activity [IGILink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEERHEDHH RDVENKLNLN GKDDINGNTS ISIEVPDGGY GWFILLAFIL YNFSTWGANS  60
   61 GYAIYLAHYL ENNTFAGGSK LDYASIGGLA FSCGLFFAPV ITWLYHIFSI QFIIGLGILF 120
  121 QGAALLLAAF SVTLWEIYLT QGVLIGFGLA FIFIPSVTLI PLWFRNKRSL ASGIGTAGSG 180
  181 LGGIVFNLGM QSILQKRGVK WALIAQCIIC TSLSTIALML TRTTHQGLRQ HKRSYKFELL 240
  241 DYDVLSNFAV WLLFGFVSFA MLGYVVLLYS LSDFTVSLGY TSKQGSYVSC MVSVGSLLGR 300
  301 PIVGHIADKY GSLTVGMILH LVMAILCWAM WIPCKNLATA IRFGLLVGSI MGTIWPTIAS 360
  361 IVTRIVGLQK LPGTFGSTWI FMAAFALVAP IIGLELRSTD TNGNDYYRTA IFVGFAYFGV 420
  421 SLCQWLLRGF IIARDEIAVR EAYSADQNEL HLNVKLSHMS KCLFRYKQLP RRV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..76] deduced N/A No confident structure predictions are available.
    2 View Details [77..473] PSI-BLAST 13.30103 No description for 1ja5A_ was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transporter activity
    		•  4.09176719149278 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.5865018981083 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.3426261924492 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.29689809004391 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  2.15783210522667 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.94035843948137 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.59419818573076 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.5181741634556 bayes_pls_golite062009
  • secondary active transmembrane transporter activity
    		•  1.22264637452409 bayes_pls_golite062009
  • polyol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • alcohol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • glycerol transmembrane transporter activity
    		•  0.812001619402678 bayes_pls_golite062009
  • binding
    		•  0.805286077372817 bayes_pls_golite062009
  • symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • solute:cation symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • cation:sugar symporter activity
    		•  0.143419068761182 bayes_pls_golite062009
  • sugar:hydrogen symporter activity
    		•  0.143419068761182 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle