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Protein Overview: PHD1

General Information:
Name(s) found: PHD1 / YKL043W [SGD]
Description(s) found:
Found 38 descriptions.
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  • Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 366 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: pseudohyphal growth [IMPLink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: transcription factor activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYHVPEMRLH YPLVNTQSNA AITPTRSYDN TLPSFNELSH QSTINLPFVQ RETPNAYANV  60
   61 AQLATSPTQA KSGYYCRYYA VPFPTYPQQP QSPYQQAVLP YATIPNSNFQ PSSFPVMAVM 120
  121 PPEVQFDGSF LNTLHPHTEL PPIIQNTNDT SVARPNNLKS IAAASPTVTA TTRTPGVSST 180
  181 SVLKPRVITT MWEDENTICY QVEANGISVV RRADNNMING TKLLNVTKMT RGRRDGILRS 240
  241 EKVREVVKIG SMHLKGVWIP FERAYILAQR EQILDHLYPL FVKDIESIVD ARKPSNKASL 300
  301 TPKSSPAPIK QEPSDNKHEI ATEIKPKSID ALSNGASTQG AGELPHLKIN HIDTEAQTSR 360
  361 AKNELS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PHD1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..194] MSA 70.103997 View MSA. No confident structure predictions are available.
    2 View Details [195..289] PSI-BLAST 85.28043 DNA-binding domain of Mlu1-box binding protein MBP1
    3 View Details [290..366] deduced N/A Confident ab initio structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  4.36949648004482 bayes_pls_golite062009
  • DNA binding
    		•  4.06494205639151 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.98559547948274 bayes_pls_golite062009
  • transcription factor activity
    		•  3.87642218322379 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.19892138828988 bayes_pls_golite062009
  • binding
    		•  2.79149251200147 bayes_pls_golite062009
  • protein binding
    		•  1.55473080522232 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.838109968340069 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle