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Protein Overview: OPT1

General Information:
Name(s) found: OPT1 / YJL212C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 799 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [IMPLink to PubMed article][ISSLink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: oligopeptide transport [IDALink to PubMed article]
    sulfur metabolic process [IEPLink to PubMed article]
    Molecular Function: proton-dependent oligopeptide secondary active transmembrane transporter activity [IDALink to PubMed article]
    oligopeptide transporter activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTIYRESDS LESEPSPTPT TIPIQINMEE EKKDAFVKNI DEDVNNLTAT TDEEDRDPES  60
   61 QKFDRHSIQE EGLVWKGDPT YLPNSPYPEV RSAVSIEDDP TIRLNHWRTW FLTTVFVVVF 120
  121 AGVNQFFSLR YPSLEINFLV AQVVCYPIGR ILALLPDWKC SKVPFFDLNP GPFTKKEHAV 180
  181 VTIAVALTSS TAYAMYILNA QGSFYNMKLN VGYQFLLVWT SQMIGYGAAG LTRRWVVNPA 240
  241 SSIWPQTLIS VSLFDSLHSR KVEKTVANGW TMPRYRFFLI VLIGSFIWYW VPGFLFTGLS 300
  301 YFNVILWGSK TRHNFIANTI FGTQSGLGAL PITFDYTQVS QAMSGSVFAT PFYVSANTYA 360
  361 SVLIFFVIVL PCLYFTNTWY AKYMPVISGS TYDNTQNKYN VTKILNEDYS INLEKYKEYS 420
  421 PVFVPFSYLL SYALNFAAVI AVFVHCILYH GKDIVAKFKD RKNGGTDIHM RIYSKNYKDC 480
  481 PDWWYLLLQI VMIGLGFVAV CCFDTKFPAW AFVIAILISL VNFIPQGILE AMTNQHVGLN 540
  541 IITELICGYM LPLRPMANLL FKLYGFIVMR QGLNLSRDLK LAMYMKVSPR LIFAVQIYAT 600
  601 IISGMVNVGV QEWMMHNIDG LCTTDQPNGF TCANGRTVFN ASIIWSLPKY LFSSGRIYNP 660
  661 LMWFFLIGLL FPLAVYAVQW KFPKFKFAKH IHTPVFFTGP GNIPPSTPYN YSLFFAMSFC 720
  721 LNLIRKRWRA WFNKYNFVMG AGVEAGVAIS VVIIFLCVQY PGGKLSWWGN NVWKRTYDND 780
  781 YKKFYTLKKG ETFGYDKWW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data OPT1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..799] Pfam 1000.0 OPT oligopeptide transporter protein No confident structure predictions are available.
    2 View Details [174..327] deduced N/A No confident structure predictions are available.
    3 View Details [328..419] deduced N/A No confident structure predictions are available.
    4 View Details [420..495] deduced N/A No confident structure predictions are available.
    5 View Details [496..617] MSA 1.225994 View MSA. No confident structure predictions are available.
    6 View Details [618..799] MSA 2.224985 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transferase activity, transferring phosphorus-containing groups
    		•  2.01281538416671 bayes_pls_golite062009
  • binding
    		•  1.94407817286887 bayes_pls_golite062009
  • transferase activity
    		•  1.60649038965008 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  1.52156836827301 bayes_pls_golite062009
  • RNA polymerase activity
    		•  1.52156836827301 bayes_pls_golite062009
  • catalytic activity
    		•  0.853948963582441 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.703245359585675 bayes_pls_golite062009
  • DNA binding
    		•  0.542083591442061 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.405555358891152 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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