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Protein Overview: HIS5

General Information:
Name(s) found: HIS5 / YIL116W [SGD]
Description(s) found:
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  • gi|729721|sp|P07172.2|HIS8_YEAST RecName: Full=Histidinol-phosphate aminotransferase; AltName: Full=Imidazole acetol-phosphate transaminase [NCBI NR]
  • gi|6322075|ref|NP_012150.1| Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts [NCBI NR]
  • pir||S48456 histidinol-phosphate transaminase (EC 2.6.1.9) - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|558690|emb|CAA86264.1| his5 [Saccharomyces cerevisiae] [NCBI NR]
  • Histidinol-phosphate aminotransferase OS=Saccharomyces cerevisiae GN=HIS5 PE=1 SV=2 [Swiss-Prot]
  • HIS5 Histidinol-phosphate aminotransferase [mips]
  • Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts [SGD]
  • HIS5, Chr IX from 142925-144082 [yeast_orfs2]
  • Chr IX from 142925-144082 [yeastorf3.fasta]
  • (P07172) Histidinol-phosphate aminotransferase (EC 2.6.1.9) (Imidazole acetol-phosphate transaminase) [4932.FASTACCERV.txt]
  • HIS5 SGDID:S0001378, Chr IX from 142925-144082, Verified ORF [yeastflysequest.fasta]
  • His5p [Saccharomyces cerevisiae]gi|558690|emb|CAA86264.1| his5 [Saccharomyces cerevisiae]gi|630079|pir||S48456 histidinol-phosphate transaminase (EC 2.6.1.9) - yeast (Saccharomyces cerevisiae)gi|729721|sp|P07172|HIS8_YEAST Histidinol-phosphate aminotr [nrdb_11152004_Chlamydomonas]
  • HIS5 SGDID:S000001378, Chr IX from 142925-144082, Verified ORF, "Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy an [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; His5p [Saccharomyces cerev [nr-271106-contam.fasta]
  • Histidinol-phosphate aminotransferase (Imidazole acetol-phosphate transaminase) [nr-271106-contam.fasta]
  • his5 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • HIS5 SGDID:S000001378, Chr IX from 142925-144082, Verified ORF, "Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Histidinol-phosphate aminotransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HIS5 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • HIS5 SGDID:S000001378, Chr IX from 142928-144085, Genome Release 64-1-1, Verified ORF, "Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts" [yeast-030211-contam.fasta]
  • HIS5 SGDID:S000001378, Chr IX from 142928-144085, Genome Release 64-2-1, Verified ORF, "Histidinol-phosphate aminotransferase; catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts" [20141208_orf_trans.fasta]
  • YIL116W SGDID:S000001378, Chr IX from 142928-144085, Genome Release 64-1-1, Verified ORF, "Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • Histidinol-phosphate aminotransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HIS5 PE=3 SV=2 [uniprot_sprot.fasta.20160308]
    • Organism: Saccharomyces cerevisiae
    Length: 385 amino acids

    Gene Ontology:
    Cellular Component: intracellular [TASLink to PubMed article]
    Biological Process: histidine biosynthetic process [TASLink to PubMed article]
    Molecular Function: histidinol-phosphate transaminase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVFDLKRIVR PKIYNLEPYR CARDDFTEGI LLDANENAHG PTPVELSKTN LHRYPDPHQL  60
   61 EFKTAMTKYR NKTSSYANDP EVKPLTADNL CLGVGSDESI DAIIRACCVP GKEKILVLPP 120
  121 TYSMYSVCAN INDIEVVQCP LTVSDGSFQM DTEAVLTILK NDSLIKLMFV TSPGNPTGAK 180
  181 IKTSLIEKVL QNWDNGLVVV DEAYVDFCGG STAPLVTKYP NLVTLQTLSK SFGLAGIRLG 240
  241 MTYATAELAR ILNAMKAPYN ISSLASEYAL KAVQDSNLKK MEATSKIINE EKMRLLKELT 300
  301 ALDYVDDQYV GGLDANFLLI RINGGDNVLA KKLYYQLATQ SGVVVRFRGN ELGCSGCLRI 360
  361 TVGTHEENTH LIKYFKETLY KLANE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SPE1 HIS5 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data HIS5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..286] PSI-BLAST 514.37734 Histidinol-phosphate aminotransferase
    2 View Details [287..385] PSI-BLAST 514.37734 Histidinol-phosphate aminotransferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • transferase activity
    		•  1.44093490824786 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • histidinol-phosphate transaminase activity
    		•  1.26617748508821 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  0.81652984148807 bayes_pls_golite062009
  • 5-aminolevulinate synthase activity
    		•  0.802089219704558 bayes_pls_golite062009
  • intramolecular transferase activity, transferring amino groups
    		•  0.659071155545801 bayes_pls_golite062009
  • binding
    		•  0.536634592992536 bayes_pls_golite062009
  • pyridoxal phosphate binding
    		•  0.16957228630576 bayes_pls_golite062009
  • vitamin B6 binding
    		•  0.16957228630576 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.013097682076602 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle