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View Structure Prediction Details

Protein: HIS5
Organism: Saccharomyces cerevisiae
Length: 385 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIS5.

Description E-value Query
Range		 Subject
Range
gi|7576444 - gi|7576444|dbj|BAA94600.1| 1-aminocyclopropane-1-carboxylate synthase [Populus euramericana]
gi|7576444 - dbj|BAA94600.1| 1-aminocyclopropane-1-carboxylate synthase [Populus euramericana]
 0.0 [25..384] [40..434]
gi|4090535 - gi|4090535|gb|AAC98809.1| ACC synthase [Carica papaya]
 0.0 [24..384] [42..438]
1A1C_SOYBN - 1-aminocyclopropane-1-carboxylate synthase OS=Glycine max GN=ACS1 PE=2 SV=1
 0.0 [23..384] [42..440]
gi|6433836, gi|6... - gi|6433836|emb|CAB60722.1| ACC synthase [Citrus sinensis], gi|6433834|emb|CAB60721.1| ACC synthase [...
 0.0 [18..384] [38..439]
gi|17266328 - gi|17266328|gb|AAL35745.1| 1-aminocyclopropanecarboxylic acid synthase [Medicago truncatula]
 0.0 [24..385] [43..441]
gi|8570043 - gi|8570043|dbj|BAA96743.1| 1-aminocyclopropane-1-carboxylate synthase [Prunus persica]
 0.0 [24..384] [44..438]
gi|1877497, gi|1... - gi|1877497|gb|AAB70885.1| 1-aminocyclopropane-1-carboxylate synthase [Pelargonium x hortorum], gi|14...
 0.0 [24..384] [45..441]
1A1C_TOBAC - 1-aminocyclopropane-1-carboxylate synthase OS=Nicotiana tabacum GN=ACS1 PE=2 SV=1
 0.0 [18..379] [38..434]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [18..379] [30..426]
gi|7209853 - gi|7209853|dbj|BAA92351.1| 1-aminocyclopropane-1-carboxylate synthase [Malus x domestica]
 0.0 [24..384] [43..438]

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Predicted Domain #1
Region A:
Residues: [1-286] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVFDLKRIVR PKIYNLEPYR CARDDFTEGI LLDANENAHG PTPVELSKTN LHRYPDPHQL  60
   61 EFKTAMTKYR NKTSSYANDP EVKPLTADNL CLGVGSDESI DAIIRACCVP GKEKILVLPP 120
  121 TYSMYSVCAN INDIEVVQCP LTVSDGSFQM DTEAVLTILK NDSLIKLMFV TSPGNPTGAK 180
  181 IKTSLIEKVL QNWDNGLVVV DEAYVDFCGG STAPLVTKYP NLVTLQTLSK SFGLAGIRLG 240
  241 MTYATAELAR ILNAMKAPYN ISSLASEYAL KAVQDSNLKK MEATSK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 514.37734
Match: 1gewA_
Description: Histidinol-phosphate aminotransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 2.29878871754893 bayes_pls_golite062009
transferase activity 1.44093490824786 bayes_pls_golite062009
transferase activity, transferring nitrogenous groups 1.28316822767388 bayes_pls_golite062009
histidinol-phosphate transaminase activity 1.26617748508821 bayes_pls_golite062009
transaminase activity 1.24990480711889 bayes_pls_golite062009
L-aspartate:2-oxoglutarate aminotransferase activity 0.81652984148807 bayes_pls_golite062009
5-aminolevulinate synthase activity 0.802089219704558 bayes_pls_golite062009
intramolecular transferase activity, transferring amino groups 0.659071155545801 bayes_pls_golite062009
binding 0.536634592992536 bayes_pls_golite062009
pyridoxal phosphate binding 0.16957228630576 bayes_pls_golite062009
vitamin B6 binding 0.16957228630576 bayes_pls_golite062009
nucleic acid binding 0.013097682076602 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [287-385] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IINEEKMRLL KELTALDYVD DQYVGGLDAN FLLIRINGGD NVLAKKLYYQ LATQSGVVVR  60
   61 FRGNELGCSG CLRITVGTHE ENTHLIKYFK ETLYKLANE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 514.37734
Match: 1gewA_
Description: Histidinol-phosphate aminotransferase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle