Protein Overview: SPO12

General Information:
Name(s) found:	SPO12 / YHR152W [SGD]
Description(s) found: Found 29 descriptions. SHOW ALL	Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis [SGD]
Organism:	Saccharomyces cerevisiae
Length:	173 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] nucleolus [IDA]
Biological Process:	regulation of exit from mitosis [IGI] mitotic cell cycle [IEP][IGI] meiosis I [IMP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNKASDQSA RTASILKTDI TRENTITRSS SSNNDNYHHH NNINNYNESA KTGEDANKEN  60
   61 IPNLEEEIAA FRIFRKKSTS NLKSSHTTSN LVKKTMFKRD LLKQDPKRKL QLQQRFASPT 120
  121 DRLVSPCSLK LNEHKVKMFG KKKKVNPMKL NFKGNLAADS EDVEIDEDEE YFY

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		PSE1 SPO12 SRV2 SUM1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SPO12	CSM1	2	Uetz P, et al. (2000)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	SPO12	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..173]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2