Protein Overview: YHL050C

General Information:
Name(s) found:	YHL050C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|731626\|sp\|P38721.1\|YHF0_YEAST RecName: Full=Uncharacterized protein YHL050C [NCBI NR] gi\|6321737\|ref\|NP_011813.1\| Putative protein of unknown function, potential Cdc28p substrate; Yhl050cp [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S48964 hypothetical protein YHL050c - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|2289855\|gb\|AAB65038.1\| unknown [Saccharomyces cerevisiae] [NCBI NR] Uncharacterized protein YHL050C OS=Saccharomyces cerevisiae GN=YHL050C PE=4 SV=1 [Swiss-Prot] Strong similarity to subtelomeric encoded proteins [mips] Putative protein of unknown function, potential Cdc28p substrate [SGD] YHL050C, Chr VIII from 445-1085,1858-3310, reverse complement [yeast_orfs2] Chr VIII from 445-1085,1858-3310, reverse complement [yeastorf3.fasta] Chr VIII from 3310-2670,1897-445, reverse complement [yeastorf5.fasta] (P38721) Hypothetical 79.0 kDa protein in CBP2 5'region [4932.FASTACCERV.txt] YHL050C SGDID:S0001042, Chr VIII from 3310-2670,1897-445, reverse complement, Uncharacterized ORF [yeastflysequest.fasta] Protein of unknown function, potential Cdc28p substrate [Saccharomyces cerevisiae]gi\|731626\|sp\|P38721\|YHF0_YEAST Hypothetical 79.0 kDa protein in CBP2 5'regiongi\|626592\|pir\|\|S48964 hypothetical protein YHL050c - yeast (Saccharomyces cerevisiae)gi\|22898 [nrdb_11152004_Chlamydomonas] YHL050C SGDID:S000001042, Chr VIII from 3310-2670,1897-445, reverse complement, Uncharacterized ORF, "Protein of unknown function, potential Cdc28p substrate" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] YHL050C SGDID:S000001042, Chr VIII from 3310-2670,1897-445, reverse complement, Uncharacterized ORF, "Putative protein of unknown function, potential Cdc28p substrate" [yeast-contam.fasta] unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Putative protein of unknown function, potential Cdc28p substrate; Yhl050cp [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Hypothetical 79.0 kDa protein in CBP2 5'region [nr-271106-contam.fasta] [chemostatdb.fasta] Uncharacterized protein YHL050C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YHL050C PE=4 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] YHL050C SGDID:S000001042, Chr VIII from 1897-445,3311-2671, Genome Release 64-1-1, reverse complement, Uncharacterized ORF, "Putative protein of unknown function, potential Cdc28p substrate" [yeast-030211-contam.fasta] YHL050C SGDID:S000001042, Chr VIII from 1897-445,3311-2671, Genome Release 64-2-1, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; potential Cdc28p substrate" [20141208_orf_trans.fasta]
Organism:	Saccharomyces cerevisiae
Length:	697 amino acids
Gene Ontology:
Cellular Component:	cellular_component [ND]
Biological Process:	biological_process [ND]
Molecular Function:	helicase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADTPSVAVQ APPGYGKTEL FHLPLIALAS KGDVEYVSFL FVPYTVLLAN CMIRLGRCGC  60
   61 LNVAPVRNFI EEGCDGVTDL YVGIYDDLAS TNFTDRIAAW ENIVECTFRT NNVKLGYLIV 120
  121 DELHNFETEV YRQSQFGGIT NLDFDAFEKA IFLSGTAPEA VADAALQRIG LTGLAKKSMD 180
  181 INELKRSEDL SRGLSSYPTR MFNLIKEKSK VPLGTNATTT ASTNVRTSAT TTASINVRTS 240
  241 ATTTASINVR TSATTTESTN SNTNATTTES TNSSTNATTT ASTNSSTNAT TTESTNASAK 300
  301 EDANKDGNAE DNRFHPVTDI NKEPYKRKGS QMVLLERKKL KAQFPNTSEN MNVLQFLGFR 360
  361 SDEIKHLFLY GIDIYFCPEG VFTQYGLCKG CQKMFELCVC WAGQKVSYRR MAWEALAVER 420
  421 MLRNDEEYKE YLEDIEPYHG DPVGYLKFFS VKRREIYSQI QRNYAWYLAI TRRRETISVL 480
  481 DSTRGKQGSQ VFRMSGRQIK ELYYKVWSNL RESKTEVLQY FLNWDEKKCQ EEWEAKDDTV 540
  541 FVEALEKVGV FQRLRSMTSA GLQGPQYVKL QFSRHHRQLR SRYELSLGMH LRDQLALGVT 600
  601 PSKVPHWTAF LSMLIGLFYN KTFRQKLEYL LEQISEVWLL PHWLDLANVE VLAADNTRVP 660
  661 LYMLMVAVHK ELDSDDVPDG RFDIILLCRD SSREVGE

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	NSE3	No Comments	Hazbun TR, et al. (2003)
View Run	RLF2	phosphorylation data - cascade search	Green EM, et al (2005)
View Run	MLP2	#24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	DOT1	YHL050C	1	Unpublished Fields Lab Data
View Screen	CPR6	YHL050C	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..53]	MSA	1.030978	View MSA. No confident structure predictions are available.
2	View Details	[54..402]	MSA	55.157997	View MSA. No confident structure predictions are available.
3	View Details	[403..697]	deduced	N/A	No confident structure predictions are available.
4	View Details	[604..697]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
binding	0.301700930786307	bayes_pls_golite062009
catalytic activity	0.176212702885001	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.83

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2