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Protein Overview: MSM1

General Information:
Name(s) found: MSM1 / YGR171C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 575 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article][IMPLink to PubMed article]
    Biological Process: methionyl-tRNA aminoacylation [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: methionine-tRNA ligase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQCRSIVHRL YSKVSHVTTP IFYPNAKPHL GHLYSSLLSD VYHRWQLFKG NLSFFTTGTD  60
   61 EHGLKIQCAS ESNGFDQPKK FVDKLYPEFV QLDKIYGINY TRFIRTTDPD HIENVMKLWE 120
  121 LCLKNGYIYM GEHKGWYSIS DETFYPESKV IKDPKNDGKY LNTESKNEVV YQSETNYFFR 180
  181 LSLFNKKIVD HIRKNPDFIF PASKRDQILK ELETGGTLPD LSISRPSARL KWGIPTPNDP 240
  241 SQKVYVWFDA LCNYLSSIGG IPSILSNATE VVSRHYSDKS NVKGQLLIPY PKEVQRNTIH 300
  301 VIGKDIAKFH TVYWPSFLLA AGLPLPRQIV VHGHWLCNGM KMSKSLGNVV DPIDMARYYG 360
  361 ADIVRWFLLE NSKLEEDGDF QEAKLYETRE LLVSKWGNLI NRCCGSKFNI ERAVMKFSDK 420
  421 ANFQFQEIFQ NEPIVSERIE NLAKLLNKSQ EVFDEKIAIF QYPQLLRHVW SIINDANTLV 480
  481 QNSKPWEREL DQQDNIIFLA METSRILSIL CQSIIPSLSQ SFLDRIDVSK EKRTINYARL 540
  541 GSDKTYGKQS NKKGREVPLK KIPFRLQEEQ TNMRS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ERG10 LEU1 MSM1
    View Details Qiu et al. (2008) MSM1 NAM2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen IST3 MSM1 1 Unpublished Fields Lab Data
    View Screen ZDS2 MSM1 1 Unpublished Fields Lab Data
    View Screen YPT53 MSM1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MSM1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..332] PSI-BLAST 818.218487 Methionyl-tRNA synthetase (MetRS)
    2 View Details [333..388]
    [437..465]    		 PSI-BLAST 818.218487 Methionyl-tRNA synthetase (MetRS)
    3 View Details [389..436]
    [466..575]    		 PSI-BLAST 818.218487 Methionyl-tRNA synthetase (MetRS)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle