YRC Public Data Repository - Protein Structure Prediction

Protein:	MSM1
Organism:	Saccharomyces cerevisiae
Length:	575 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MSM1.

Description	E-value	Query Range	Subject Range
SYM_BACHD - Methionyl-tRNA synthetase OS=Bacillus halodurans GN=metG PE=3 SV=1 SYM_BACHD - Methionine--tRNA ligase OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 91...	0.0	[10..570]	[3..536]
SYM_GEOSE - Methionine--tRNA ligase OS=Geobacillus stearothermophilus GN=metG PE=3 SV=1	0.0	[11..575]	[2..542]
SYM_BACSU - Methionine--tRNA ligase OS=Bacillus subtilis GN=metG PE=3 SV=1 SYM_BACSU - Methionine--tRNA ligase OS=Bacillus subtilis (strain 168) GN=metG PE=3 SV=1 gi\|221312169 - gi\|221312169\|ref\|ZP_03593974.1\| methionyl-tRNA synthetase [Bacillus subtilis subsp. subtilis str. NC... gi\|221317102 - gi\|221317102\|ref\|ZP_03598396.1\| methionyl-tRNA synthetase [Bacillus subtilis subsp. subtilis str. JH... gi\|221321365 - gi\|221321365\|ref\|ZP_03602659.1\| methionyl-tRNA synthetase [Bacillus subtilis subsp. subtilis str. SM...	0.0	[11..531]	[4..494]
SYMM_YEAST - Methionine--tRNA ligase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=M... MSM1 - Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein syn...	0.0	[1..575]	[1..575]
SYM_STAAM - Methionine--tRNA ligase OS=Staphylococcus aureus (strain Mu50 / ATCC 700699) GN=metG PE=3 SV=1 gi\|269202110\|ref... - methionyl-tRNA synthetase [Staphylococcus aureus subsp. aureus ED98] SYM_STAAN - Methionine--tRNA ligase OS=Staphylococcus aureus (strain N315) GN=metG PE=1 SV=1 gi\|253735224, gi... - gi\|253735224\|ref\|ZP_04869389.1\| methionyl-tRNA synthetase [Staphylococcus aureus subsp. aureus TCH13... gi\|253316233 - gi\|253316233\|ref\|ZP_04839446.1\| methionyl-tRNA synthetase [Staphylococcus aureus subsp. aureus str. ... gi\|255005283 - gi\|255005283\|ref\|ZP_05143884.2\| methionyl-tRNA synthetase [Staphylococcus aureus subsp. aureus Mu50-... gi\|156720953, gi... - gi\|156978818\|ref\|YP_001441077.1\| methionyl-tRNA synthetase [Staphylococcus aureus subsp. aureus Mu3]... gi\|25293125 - pir\|\|C89815 methionyl-tRNA synthetase [imported] - Staphylococcus aureus (strain N315)	0.0	[12..570]	[3..535]
SYM_CLOAB - Methionine--tRNA ligase OS=Clostridium acetobutylicum GN=metG PE=3 SV=1 SYM_CLOAB - Methionine--tRNA ligase OS=Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 57...	0.0	[10..573]	[2..524]
SYM_LISIN - Methionine--tRNA ligase OS=Listeria innocua serovar 6a (strain CLIP 11262) GN=metG PE=3 SV=1 SYM_LISIN - Methionine--tRNA ligase OS=Listeria innocua GN=metG PE=3 SV=1	0.0	[10..570]	[3..537]
gi\|126941340, gi... - gi\|254901038\|ref\|ZP_05260962.1\| methionyl-tRNA synthetase [Listeria monocytogenes J0161], gi\|1531862... gi\|127766781, gi... - gi\|254913894\|ref\|ZP_05263906.1\| methionyl-tRNA synthetase [Listeria monocytogenes J2818], gi\|1531893... gi\|254832524, gi... - gi\|254832524\|ref\|ZP_05237179.1\| methionyl-tRNA synthetase [Listeria monocytogenes 10403S], gi\|153198... gi\|153177834, gi... - gi\|254938315\|ref\|ZP_05270012.1\| methionyl-tRNA synthetase [Listeria monocytogenes F6900], gi\|1531778... gi\|255026302 - gi\|255026302\|ref\|ZP_05298288.1\| methionyl-tRNA synthetase [Listeria monocytogenes FSL J2-003] SYM_LISMO - Methionine--tRNA ligase OS=Listeria monocytogenes GN=metG PE=3 SV=1 gi\|133731347, gi... - gi\|254829268\|ref\|ZP_05233955.1\| methionyl-tRNA synthetase [Listeria monocytogenes FSL N3-165], gi\|15... gi\|255029121 - gi\|255029121\|ref\|ZP_05301072.1\| methionyl-tRNA synthetase [Listeria monocytogenes LO28] gi\|224500370 - gi\|224500370\|ref\|ZP_03668719.1\| methionyl-tRNA synthetase [Listeria monocytogenes Finland 1988] SYM_LISMO - Methionine--tRNA ligase OS=Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) GN=metG... gi\|224503503 - gi\|224503503\|ref\|ZP_03671810.1\| methionyl-tRNA synthetase [Listeria monocytogenes FSL R2-561]	0.0	[10..570]	[3..537]
SYM_CLOPE - Methionine--tRNA ligase OS=Clostridium perfringens (strain 13 / Type A) GN=metG PE=3 SV=1 SYM_CLOPE - Methionine--tRNA ligase OS=Clostridium perfringens GN=metG PE=3 SV=1	0.0	[12..567]	[3..520]

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Predicted Domain #1

Region A:
Residues: [1-332]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQCRSIVHRL YSKVSHVTTP IFYPNAKPHL GHLYSSLLSD VYHRWQLFKG NLSFFTTGTD  60
   61 EHGLKIQCAS ESNGFDQPKK FVDKLYPEFV QLDKIYGINY TRFIRTTDPD HIENVMKLWE 120
  121 LCLKNGYIYM GEHKGWYSIS DETFYPESKV IKDPKNDGKY LNTESKNEVV YQSETNYFFR 180
  181 LSLFNKKIVD HIRKNPDFIF PASKRDQILK ELETGGTLPD LSISRPSARL KWGIPTPNDP 240
  241 SQKVYVWFDA LCNYLSSIGG IPSILSNATE VVSRHYSDKS NVKGQLLIPY PKEVQRNTIH 300
  301 VIGKDIAKFH TVYWPSFLLA AGLPLPRQIV VH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	818.218487
Match:	1a8h__
Description:	Methionyl-tRNA synthetase (MetRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [333-388]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GHWLCNGMKM SKSLGNVVDP IDMARYYGAD IVRWFLLENS KLEEDGDFQE AKLYET

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [437-465]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERIENLAKLL NKSQEVFDEK IAIFQYPQL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	818.218487
Match:	1a8h__
Description:	Methionyl-tRNA synthetase (MetRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [389-436]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RELLVSKWGN LINRCCGSKF NIERAVMKFS DKANFQFQEI FQNEPIVS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [466-575]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRHVWSIIND ANTLVQNSKP WERELDQQDN IIFLAMETSR ILSILCQSII PSLSQSFLDR  60
   61 IDVSKEKRTI NYARLGSDKT YGKQSNKKGR EVPLKKIPFR LQEEQTNMRS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	818.218487
Match:	1a8h__
Description:	Methionyl-tRNA synthetase (MetRS)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits