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Protein Overview: CLB6

General Information:
Name(s) found: CLB6 / YGR109C [SGD]
Description(s) found:
Found 28 descriptions.
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  • B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 380 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: G1/S transition of mitotic cell cycle [IGILink to PubMed article]
    positive regulation of DNA replication [IMPLink to PubMed article]
    regulation of S phase of mitotic cell cycle [IMPLink to PubMed article]
    premeiotic DNA synthesis [IGILink to PubMed article][IMPLink to PubMed article]
    regulation of cyclin-dependent protein kinase activity [TAS]
    Molecular Function: cyclin-dependent protein kinase regulator activity [IEPLink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNCIPSPISE RKIQINNEDC IGKENAFHTI PRESSINLTP HSTNEKKVLS EVNSNKIDSL  60
   61 QLPRGKLQRD STHLEKTRKR QLSNDSTDPI EPKTVKKIKC HQWKNLDSIE MDDPFMVAEY 120
  121 TDSIFSHLYE KEIQMLPTHN YLMDTQSPYH LKSSMRALLI DWLVEVHEKF HCLPETLFLA 180
  181 INLLDRFLSQ NVVKLNKLQL LCITCLFIAC KFEEVKLPKI TNFAYVTDGA ATVEGIRKAE 240
  241 LFVLSSLGYN ISLPNPLNFI RRISKADNYC IETRNMAKFI MEYSICCNKF IHLKPSYLAA 300
  301 MSMYIARKIK NENSKWDETF IHYSGGIDIE SDPAFKDFIS ELVEDIAVPD TNLDSLRLKY 360
  361 KKPKHGMVYF KVFDWCKQKR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) CDC28 CLB1 CLB2 CLB3 CLB4 CLB5 CLB6 CLN1 CLN2 CLN3
    View Details Qiu et al. (2008) CLB1 CLB2 CLB3 CLB4 CLB5 CLB6 CLN1 CLN2 CLN3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RBA50 No Comments Hazbun TR, et al. (2003)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..91] deduced N/A No confident structure predictions are available.
    2 View Details [92..130]
    [256..380]    		 PSI-BLAST 328.855515 Cyclin A
    3 View Details [131..255] PSI-BLAST 328.855515 Cyclin A


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle