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Protein Overview: TPC1

General Information:
Name(s) found: TPC1 / YGR096W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 314 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial envelope [IDALink to PubMed article]
    Biological Process: thiamin pyrophosphate transport [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: thiamin transmembrane transporter activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFKEEDSLRK GQNVAAWKTL LAGAVSGLLA RSITAPMDTI KIRLQLTPAN GLKPFGSQVM  60
   61 EVARSMIKNE GIRSFWKGNI PGSLLYVTYG SAQFSSYSLF NRYLTPFGLE ARLHSLVVGA 120
  121 FAGITSSIVS YPFDVLRTRL VANNQMHSMS ITREVRDIWK LEGLPGFFKG SIASMTTITL 180
  181 TASIMFGTYE TIRIYCDENE KTTAAHKKWE LATLNHSAGT IGGVIAKIIT FPLETIRRRM 240
  241 QFMNSKHLEK FSRHSSVYGS YKGYGFARIG LQILKQEGVS SLYRGILVAL SKTIPTTFVS 300
  301 FWGYETAIHY LRMY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) TPC1 YEA6

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data TPC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..314] ORFEUS 7.04 Peroxisomal acyl-CoA oxidase-II, domains 3 and 4; Peroxisomal acyl-CoA oxidase-II, domains 1 and 2


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle