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Protein Overview: MET13

General Information:
Name(s) found: MET13 / YGL125W [SGD]
Description(s) found:
Found 10 descriptions.
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  • Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 599 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    mitochondrial large ribosomal subunit [IDALink to PubMed article]
    Biological Process: sulfur amino acid biosynthetic process [TASLink to PubMed article]
    translation [IDALink to PubMed article]
    methionine metabolic process [IMPLink to PubMed article][TASLink to PubMed article]
    Molecular Function: structural constituent of ribosome [IDALink to PubMed article]
    methylenetetrahydrofolate reductase (NADPH) activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKITEKLEQH RQTSGKPTYS FEYFVPKTTQ GVQNLYDRMD RMYEASLPQF IDITWNAGGG  60
   61 RLSHLSTDLV ATAQSVLGLE TCMHLTCTNM PISMIDDALE NAYHSGCQNI LALRGDPPRD 120
  121 AENWTPVEGG FQYAKDLIKY IKSKYGDHFA IGVAGYPECH PELPNKDVKL DLEYLSRRST 180
  181 GGDFIITQMF YDVDNLLNWC SQVRAAGMDV PIIPGIMPIT TYAAFLRRIQ WGQISIPQHF 240
  241 SSRLDPIKDD DELVRDIGTN LIVEMCQKLL DSGYVSHLHI YTMNLEKAPL MILERLNILP 300
  301 TESEFNAHPL AVLPWRKSLN PKRKNEEVRP IFWKRRPYSY VARTSQWAVD EFPNGRFGDS 360
  361 SSPAFGDLDL CGSDLIRQSA NKCLELWSTP TSINDVAFLV INYLNGNLKC LPWSDIPIND 420
  421 EINPIKAHLI ELNQHSIITI NSQPQVNGIR SNDKIHGWGP KDGYVYQKQY LEFMLPKTKL 480
  481 PKLIDTLKNN EFLTYFAIDS QGDLLSNHPD NSKSNAVTWG IFPGREILQP TIVEKISFLA 540
  541 WKEEFYHILN EWKLNMNKYD KPHSAQFIQS LIDDYCLVNI VDNDYISPDD QIHSILLSL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..325] PSI-BLAST 419.035458 Methylenetetrahydrofolate reductase
    2 View Details [326..599] MSA 1.012911 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle