YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: ALK1

General Information:
Name(s) found: ALK1 / YGL021W [SGD]
Description(s) found:
Found 25 descriptions.
SHOW ALL
  • Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk2p and to mammalian haspins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 760 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: mitosis [IEPLink to PubMed articleLink to PubMed article]
    protein amino acid phosphorylation [IDALink to PubMed article]
    Molecular Function: protein kinase activity [IDALink to PubMed article]
    protein serine/threonine kinase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLHFDIVIQ LLSSHTLKSH QVEPPMDFET SFEEFVEDKR FIALEVSDND DDCDTDLTAD  60
   61 TADELESSAI LKMRESDASL NVTTGNNTSR KTTSNSKKRW SLLSNHSAVS SSKSKKRWSV 120
  121 LSSSFTSESH KDRESRNVLQ QKRKSLQSYS SLDTVASNSS ISASSSLKRS STGLSLRQLF 180
  181 TKIGINDDIS QPGIGIPQGK ENLPPTMGKK NSSIASTSSE NRLRTPLKPL VNHSKRPTSQ 240
  241 PQQQQPLYNA SLSSRRSSIS STVSSSSSSK WRFWKRNKNQ TPALLQPDHH SLKTFPAVNR 300
  301 RDSMTPVEPR NMVKHKTSFS DFHKTIFSSN TYSESSDTIS SMEITLKNKA SSSSLSLNVL 360
  361 KKRNSQSSLK HKSSHASLQK FKRNKGKSSM IAPSTATNSS NDDSCSYSSK NSTLSHRISL 420
  421 PVPDQVSRDK IQNKLRYSTS LLSLNSKSSL PMNKNDHDET LLRQILLNCD IKRILNPAKG 480
  481 DVLPLINDVN HLSSIQLTSN VWQIGEVICK KVSLGTIDDI TWDRKFLSLQ ELEKLKIMQQ 540
  541 KFDGIPQLLK SFVVKEANGG LYLYLLFKDH GTPISLISLK NWKQILKIFW SCAGIIHGLE 600
  601 KNLKFEHRNL TLDNILIDGN GNITIIDFKC SRLQTPQDDV LYLRLDHPLF FLNGKDKSKI 660
  661 NEYQYQFEFE IYQSMRILLN MDASAFEPMT NLYWLYYLSR VLLKFGDRKL GKNDANRDKM 720
  721 ARVINHLEMN LAVHKRGGQL FKRLETEDIK NTGDLLKLYK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ALK1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..454] deduced N/A No confident structure predictions are available.
    2 View Details [455..532]
    [551..567]    		 PSI-BLAST 80.69897 cAMP-dependent PK, catalytic subunit
    3 View Details [533..550]
    [568..760]    		 PSI-BLAST 80.69897 cAMP-dependent PK, catalytic subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • protein kinase activity
    		•  5.08693983533348 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  4.80278598786839 bayes_pls_golite062009
  • kinase activity
    		•  4.59756610116144 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.25355168820731 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.23864440079487 bayes_pls_golite062009
  • transferase activity
    		•  3.26787750561728 bayes_pls_golite062009
  • ATP binding
    		•  1.87003701072722 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.82650528610717 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.79644024762454 bayes_pls_golite062009
  • binding
    		•  1.69939147712641 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.56978145564551 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.56956819263374 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.54471996792105 bayes_pls_golite062009
  • nucleotide binding
    		•  1.53595022832543 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • protein binding
    		•  1.17747188575743 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.17063753242103 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.05410128646972 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.98751004123886 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.439470338563384 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.0936583701619971 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle