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Protein Overview: ERJ5

General Information:
Name(s) found: ERJ5 / YFR041C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 295 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IDALink to PubMed articleLink to PubMed article]
    Biological Process: telomere maintenance [IMPLink to PubMed article]
    protein folding [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNGYWKPALV VLGLVSLSYA FTTIETEIFQ LQNEISTKYG PDMNFYKFLK LPKLQNSSTK  60
   61 EITKNLRKLS KKYHPDKNPK YRKLYERLNL ATQILSNSSN RKIYDYYLQN GFPNYDFHKG 120
  121 GFYFSRMKPK TWFLLAFIWI VVNIGQYIIS IIQYRSQRSR IENFISQCKQ QDDTNGLGVK 180
  181 QLTFKQHEKD EGKSLVVRFS DVYVVEPDGS ETLISPDTLD KPSVKNCLFW RIPASVWNMT 240
  241 FGKSVGSAGK EEIITDSKKY DGNQTKKGNK VKKGSAKKGQ KKMELPNGKV IYSRK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ERJ5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..143] PSI-BLAST 53.144602 DnaJ chaperone, N-terminal (J) domain
    2 View Details [144..295] PSI-BLAST 14.522879 Cysteine-rich domain of the chaperone protein DnaJ.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • unfolded protein binding
    		•  3.04403163860617 bayes_pls_golite062009
  • heat shock protein binding
    		•  2.17994194200939 bayes_pls_golite062009
  • chaperone binding
    		•  1.61155546076854 bayes_pls_golite062009
  • binding
    		•  1.60921541945619 bayes_pls_golite062009
  • protein binding
    		•  0.912937133925792 bayes_pls_golite062009
  • Hsp70 protein binding
    		•  0.541755903922701 bayes_pls_golite062009
  • catalytic activity
    		•  0.106988907594358 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle