Protein Overview: ADK2

General Information:
Name(s) found:	ADK2 / YER170W [SGD]
Description(s) found: Found 29 descriptions. SHOW ALL	Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background [SGD]
Organism:	Saccharomyces cerevisiae
Length:	225 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA] mitochondrial inner membrane [IDA ]
Biological Process:	nucleotide metabolic process [IDA]
Molecular Function:	adenylate kinase activity [IDA ]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKADAKQITH LLKPLRLLLL GAPGSGKGTQ TSRLLKQIPQ LSSISSGDIL RQEIKSESTL  60
   61 GREATTYIAQ GKLLPDDLIT RLITFRLSAL GWLKPSAMWL LDGFPRTTAQ ASALDELLKQ 120
  121 HDASLNLVVE LDVPESTILE RIENRYVHVP SGRVYNLQYN PPKVPGLDDI TGEPLTKRLD 180
  181 DTAEVFKKRL EEYKKTNEPL KDYYKKSGIF GTVSGETSDI IFRNY

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		ADK1 ADK2 YNK1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SWI5	ADK2	1	Unpublished Fields Lab Data
View Screen	MIG1	ADK2	1	Unpublished Fields Lab Data
View Screen	IST3	ADK2	1	Unpublished Fields Lab Data
View Screen	IPL1	ADK2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	ADK2	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..225]	PSI-BLAST	504.512579	Adenylate kinase; Microbial and mitochondrial ADK, insert "zinc finger" domain

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
nucleobase, nucleoside, nucleotide kinase activity	5.63633783771436	bayes_pls_golite062009
nucleotide kinase activity	4.87013305162694	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	4.82340609517643	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	4.71956130169341	bayes_pls_golite062009
substrate-specific transporter activity	4.0949233879946	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	3.99447661719154	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	3.87925071606336	bayes_pls_golite062009
adenylate kinase activity	3.67594732794865	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.42302963379604	bayes_pls_golite062009
ion transmembrane transporter activity	3.18231927518784	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	3.06199686145935	bayes_pls_golite062009
cation transmembrane transporter activity	2.98215729643952	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
nucleic acid binding	2.11222585187695	bayes_pls_golite062009
DNA binding	1.7904783386531	bayes_pls_golite062009
transcription regulator activity	1.68903321260301	bayes_pls_golite062009
ribonucleotide binding	1.53142082854758	bayes_pls_golite062009
purine nucleotide binding	1.52938239070386	bayes_pls_golite062009
purine ribonucleotide binding	1.52887308780164	bayes_pls_golite062009
nucleotide binding	1.52746968836881	bayes_pls_golite062009
ATP binding	1.23942044024113	bayes_pls_golite062009
protein binding	1.22129154759482	bayes_pls_golite062009
adenyl ribonucleotide binding	1.21044170258803	bayes_pls_golite062009
adenyl nucleotide binding	1.19481945569892	bayes_pls_golite062009
kinase activity	1.11120928120082	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
guanylate kinase activity	0.98934362137863	bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism	0.938652092720669	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.908046791062776	bayes_pls_golite062009
structural constituent of ribosome	0.738234102557832	bayes_pls_golite062009
motor activity	0.68122766055454	bayes_pls_golite062009
cation-transporting ATPase activity	0.635625372639205	bayes_pls_golite062009
transcription factor activity	0.603758349693077	bayes_pls_golite062009
CTP synthase activity	0.554689818807922	bayes_pls_golite062009
microtubule motor activity	0.48522137429998	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.421921195209539	bayes_pls_golite062009
protein kinase activity	0.351308564667977	bayes_pls_golite062009
translation regulator activity	0.29096092258568	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.274994961137851	bayes_pls_golite062009
formate-tetrahydrofolate ligase activity	0.21533099279384	bayes_pls_golite062009
transferase activity	0.175269600441384	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	0.17485591642323	bayes_pls_golite062009
helicase activity	0.0775311459068899	bayes_pls_golite062009
structural molecule activity	0.0558641287316701	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2