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Protein Overview: AGE1

General Information:
Name(s) found: AGE1 / YDR524C [SGD]
Description(s) found:
Found 27 descriptions.
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  • ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 482 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: ER to Golgi vesicle-mediated transport [IGILink to PubMed article][ISSLink to PubMed article]
    intra-Golgi vesicle-mediated transport [IGILink to PubMed article][ISSLink to PubMed article]
    Molecular Function: ARF GTPase activator activity [IDALink to PubMed article][IGILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFYTTDINK NVVPLFSKGT VARTASKAQY PSWCNNALKL TNILLKSLRC KFQTNRCEDD  60
   61 RGFEVYCVIL KSIALLMAAK ESLILLQIPP SLPSGFPFRS PQLSFTYLST RLSGSQHKST 120
  121 HSHHINHQTH PIHSSSSNSN SNNRIPTKTD SSKQHTQHFS FANAGASNRD ELLSIVRKID 180
  181 KSNLKCCDCG STATVEWVSI NLLCILCIKC SGVHRSLGSH ISKIRSLTLD NFTSLELMHL 240
  241 LQNNVSNSNV NAIYESNLRN FPVKKITANS DDSERSKFII DKYQFKKFVI DSNQGREASL 300
  301 KSLIKAIHLD SVFMMQRAIA QSKYSLRELT ASEKEQNDLN HSSIFQYSLK HYEIVDGTPI 360
  361 FFITEFLLCN GIHIDNLPKI TTNWSPKVLE YWETKLEMYG TFQAVNTSRP RSGPHLNMHS 420
  421 NVDSASSYNK KHDLRVNIPE RSASASKRWS LSSIPKSSQN LMSPTNLLTM HKSLKLAKKD 480
  481 KK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data AGE1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..152] PSI-BLAST 2.30103 Tapp1
    2 View Details [153..294] PSI-BLAST 227.27013 Pyk2-associated protein beta; Pyk2-associated protein beta ARF-GAP domain
    3 View Details [295..414] PSI-BLAST 227.27013 Pyk2-associated protein beta; Pyk2-associated protein beta ARF-GAP domain
    4 View Details [415..482] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle