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Protein Overview: IZH1

General Information:
Name(s) found: IZH1 / YDR492W [SGD]
Description(s) found:
Found 31 descriptions.
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  • Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 316 amino acids

    Gene Ontology:
    Cellular Component: membrane [ISSLink to PubMed article][TASLink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: response to zinc ion [ISSLink to PubMed article]
    lipid metabolic process [TASLink to PubMed article]
    cellular zinc ion homeostasis [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: metal ion binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSITTTRRRN QDSVCCKATR ASIKVEAVSG QTVFEKQKLL HNFDELPEWQ KDNDKILTGY  60
   61 VRETLSWKKC LYSLFYWNNE TVNIYTHLVP AIVYFVFAIT LTNYFLIPVF PSTSWSDYTV 120
  121 INIFLMGAFS CLMCSSCFHC MKQHSEKQSN FWSKLDYLGI ISLISCSMIP IIYFGYFDHI 180
  181 SYFSLFTIVT LVLATFCTVC VLHDKFNTST FRPFRAMFFI LFGFSGLLPL TTGFFKFGIQ 240
  241 GVLNRIKVSF VFWEALFYIS GAVIYGFRIP ETLAPGKFDF FGSSHQIFHI MVVLGSVCHL 300
  301 KAIIDSYKLM HSHIHP

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) IZH1 IZH4

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data IZH1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..316] Pfam 129.69897 Haemolysin-III related No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle