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Protein Overview: LRS4

General Information:
Name(s) found: LRS4 / YDR439W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 347 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    condensed nuclear chromosome kinetochore [IDALink to PubMed article]
    nucleolus [IDALink to PubMed article]
    Biological Process: chromatin silencing at rDNA [IDALink to PubMed article]
    homologous chromosome segregation [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTLLQLLSN YYKAKLDSER IYNEYVQSQY EFASLDKLNN NKGDPKKVVD ETLFLQRQIA  60
   61 QLNKQLQLSF QENEKLLSVQ KNQKALYQSK LSSKDAFIDD LKLKLKVEQI SVDKHNKERT 120
  121 PSTGRDEQQR NSKAAHTSKP TIHLLSPIVN RDKPNNQTND RGGNDPDSPT SQRRSRGLRS 180
  181 LLSSGKNTIF DSISKNLDDE INENAHIRND TTSSKIAGKS PSRLSALQKS PELRKERNNM 240
  241 ILKEHILRSK DDQNITSSRK LDNIELSSIG DSTAMTSRSS TVNANDILGN EENDGITKLK 300
  301 RVNKLTSSPV KRDCSTNKKR KLTKQRIATL PNSDEELSNN LNVDEFV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CSM1 LRS4
    View Details Qiu et al. (2008) CSM1 LRS4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data LRS4 and NOP56 Huh WK, et al. (2003)
    View Data LRS4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..347] deduced N/A No confident structure predictions are available.
    2 View Details [255..347] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle