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Protein Overview: HPT1

General Information:
Name(s) found: HPT1 / YDR399W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 221 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: GMP salvage [IDALink to PubMed article]
    IMP salvage [IDALink to PubMed article]
    Molecular Function: hypoxanthine phosphoribosyltransferase activity [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSANDKQYIS YNNVHQLCQV SAERIKNFKP DLIIAIGGGG FIPARILRTF LKEPGVPTIR  60
   61 IFAIILSLYE DLNSVGSEVE EVGVKVSRTQ WIDYEQCKLD LVGKNVLIVD EVDDTRTTLH 120
  121 YALSELEKDA AEQAKAKGID TEKSPEMKTN FGIFVLHDKQ KPKKADLPAE MLNDKNRYFA 180
  181 AKTVPDKWYA YPWESTDIVF HTRMAIEQGN DIFIPEQEHK Q

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) APT1 HPT1 XPT1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data HPT1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..221] PSI-BLAST 32.221849 Hypoxantine-guanine PRTase (HGPRTase)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transferase activity, transferring glycosyl groups
    		•  3.91023158228049 bayes_pls_golite062009
  • hypoxanthine phosphoribosyltransferase activity
    		•  3.89356447922614 bayes_pls_golite062009
  • adenine phosphoribosyltransferase activity
    		•  3.83339863213875 bayes_pls_golite062009
  • transferase activity, transferring pentosyl groups
    		•  2.53679639481311 bayes_pls_golite062009
  • uracil phosphoribosyltransferase activity
    		•  2.36237864658341 bayes_pls_golite062009
  • catalytic activity
    		•  2.30431811394775 bayes_pls_golite062009
  • transferase activity
    		•  2.03376808731027 bayes_pls_golite062009
  • amidophosphoribosyltransferase activity
    		•  1.51802880667162 bayes_pls_golite062009
  • ribose phosphate diphosphokinase activity
    		•  1.18255665419929 bayes_pls_golite062009
  • diphosphotransferase activity
    		•  0.749909396904601 bayes_pls_golite062009
  • purine binding
    		•  0.745430157183377 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.552133387792911 bayes_pls_golite062009
  • binding
    		•  0.535390228935555 bayes_pls_golite062009
  • DNA binding
    		•  0.439741935655503 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.396538943915776 bayes_pls_golite062009
  • orotate phosphoribosyltransferase activity
    		•  0.148898393751978 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle