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Protein Overview: UPC2

General Information:
Name(s) found: UPC2 / YDR213W [SGD]
Description(s) found:
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  • gi|6320419|ref|NP_010499.1| Sterol regulatory element binding protein, induces transcription of sterol transport and biosynthetic genes; involved in the anaerobic induction of DAN/TIR mannoproteins and seripauperins; binucleate zinc cluster protein; Ecm22 [NCBI NR]
  • gi|60390754|sp|Q12151.1|UPC2_YEAST RecName: Full=Sterol uptake control protein 2; AltName: Full=Mannoprotein regulation by oxygen protein 4 [NCBI NR]
  • pir||S61580 probable membrane protein YDR213w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1204154|emb|CAA92356.1| unknown [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1122346|emb|CAA92364.1| unknown [Saccharomyces cerevisiae] [NCBI NR]
  • Sterol uptake control protein 2 OS=Saccharomyces cerevisiae GN=UPC2 PE=1 SV=1 [Swiss-Prot]
  • UPC2 Regulatory protein involved in control of sterol uptake [mips]
  • Sterol regulatory element binding protein, induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; Ecm22p homolog; relocates from intracellular membranes to perinuclear foci on sterol depletion [SGD]
  • UPC2, Chr IV from 889743-892484 [yeast_orfs2]
  • Chr IV from 889743-892484 [yeastorf3.fasta]
  • >Q12151 (Q12151) Hypothetical protein YD8142 [4932.FASTACCERV.txt]
  • UPC2 SGDID:S0002621, Chr IV from 889744-892485, Verified ORF [yeastflysequest.fasta]
  • UPC2 SGDID:S0002621, Chr IV from 889746-892487, Verified ORF [10112005cervSGD.fasta]
  • Upc2p [Saccharomyces cerevisiae]gi|1122346|emb|CAA92364.1| unknown [Saccharomyces cerevisiae]gi|1204154|emb|CAA92356.1| unknown [Saccharomyces cerevisiae]gi|2132483|pir||S61580 probable membrane protein YDR213w - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas]
  • (Q12151) Hypothetical protein YD8142.14 (Hypothetical protein YD8142B.05) [cerv4932.FASTAC]
  • UPC2 SGDID:S000002621, Chr IV from 889746-892487, Verified ORF, "Sterol regulatory element binding protein, induces transcription of sterol transport and biosynthetic genes; involved in the anaerobic induction of DAN/TIR mannoproteins and seripauperins; b [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • UPC2 SGDID:S000002621, Chr IV from 889748-892489, Verified ORF, "Sterol regulatory element binding protein, induces transcription of sterol transport and biosynthetic genes; involved in the anaerobic induction of DAN/TIR mannoproteins and seripauperins; b [yeast-contam.fasta]
  • UPC2 SGDID:S000002621, Chr IV from 889749-892490, Verified ORF, "Sterol regulatory element binding protein, induces transcription of sterol transport and biosynthetic genes; involved in the anaerobic induction of DAN/TIR mannoproteins and seripauperins; b [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • UPC2 SGDID:S000002621, Chr IV from 889749-892490, Verified ORF, "Sterol regulatory element binding protein, induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; Ecm22p homolog; relocates from intracellular membranes to perinucl [yeast-200209-contam.fasta]
  • Sterol uptake control protein 2 (Mannoprotein regulation by oxygen protein 4) [nr-271106-contam.fasta]
  • unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Sterol regulatory element binding protein, induces transcription of sterol transport and biosynthetic genes; involved in the anaerobic induction of DAN/TIR mannoproteins and seripauperins; binucleate zinc cluster protein; Ecm22p homolog; Upc2p [Saccharomy [nr-271106-contam.fasta]
  • UPC2 SGDID:S000002621, Chr IV from 889749-892490, Verified ORF, "Sterol regulatory element binding protein, induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; Ecm22p homolog; relocates from intracellular membranes to perinuclear foci on sterol depletion" [yeast-bovrabprots.fasta]
  • UPC2 SGDID:S000002621, Chr IV from 889748-892489, Verified ORF, "Sterol regulatory element binding protein, induces transcription of sterol transport and biosynthetic genes; involved in the anaerobic induction of DAN/TIR mannoproteins and seripauperins; binucleate zinc cluster protein; Ecm22p homolog" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • Sterol uptake control protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UPC2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • UPC2 SGDID:S000002621, Chr IV from 889751-892492, Genome Release 64-1-1, Verified ORF, "Sterol regulatory element binding protein, induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; Ecm22p homolog; relocates from intracellular membranes to perinuclear foci on sterol depletion" [yeast-030211-contam.fasta]
  • UPC2 SGDID:S000002621, Chr IV from 889751-892492, Genome Release 64-2-1, Verified ORF, "Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YDR213W SGDID:S000002621, Chr IV from 889751-892492, Genome Release 64-1-1, Verified ORF, "Sterol regulatory element binding protein, induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; Ecm22p homolog; relocates from intracellular membranes to perinuclear foci on sterol depletion" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 913 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IPILink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: steroid metabolic process [IMPLink to PubMed article]
    sterol biosynthetic process [IMPLink to PubMed article]
    Molecular Function: RNA polymerase II transcription factor activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEVGIQNHK KAVTKPRRRE KVIELIEVDG KKVSTTSTGK RKFHNKSKNG CDNCKRRRVK  60
   61 CDEGKPACRK CTNMKLECQY TPIHLRKGRG ATVVKYVTRK ADGSVESDSS VDLPPTIKKE 120
  121 QTPFNDIQSA VKASGSSNDS FPSSASTTKS ESEEKSSAPI EDKNNMTPLS MGLQGTINKK 180
  181 DMMNNFFSQN GTIGFGSPER LNSGIDGLLL PPLPSGNMGA FQLQQQQQVQ QQSQPQTQAQ 240
  241 QASGTPNERY GSFDLAGSPA LQSTGMSLSN SLSGMLLCNR IPSGQNYTQQ QLQYQLHQQL 300
  301 QLQQHQQVQL QQYQQLRQEQ HQQVQQQQQE QLQQYQQHFL QQQQQVLLQQ EQQPNDEEGG 360
  361 VQEENSKKVK EGPLQSQTSE TTLNSDAATL QADALSQLSK MGLSLKSLST FPTAGIGGVS 420
  421 YDFQELLGIK FPINNGNSRA TKASNAEEAL ANMQEHHERA AASVKENDGQ LSDTKSPAPS 480
  481 NNAQGGSASI MEPQAADAVS TMAPISMIER NMNRNSNISP STPSAVLNDR QEMQDSISSL 540
  541 GNLTKAALEN NEPTISLQTS QTENEDDASR QDMTSKINNE ADRSSVSAGT SNIAKLLDLS 600
  601 TKGNLNLIDM KLFHHYCTKV WPTITAAKVS GPEIWRDYIP ELAFDYPFLM HALLAFSATH 660
  661 LSRTETGLEQ YVSSHRLDAL RLLREAVLEI SENNTDALVA SALILIMDSL ANASGNGTVG 720
  721 NQSLNSMSPS AWIFHVKGAA TILTAVWPLS ERSKFHNIIS VDLSDLGDVI NPDVGTITEL 780
  781 VCFDESIADL YPVGLDSPYL ITLAYLDKLH REKNQGDFIL RVFTFPALLD KTFLALLMTG 840
  841 DLGAMRIMRS YYKLLRGFAT EVKDKVWFLE GVTQVLPQDV DEYSGGGGMH MMLDFLGGGL 900
  901 PSMTTTNFSD FSL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BUL2 UPC2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data UPC2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..166] PSI-BLAST 46.502279 PPR1
    2 View Details [167..645] deduced N/A No confident structure predictions are available.
    3 View Details [646..794] MSA 1.004965 View MSA. No confident structure predictions are available.
    4 View Details [795..913] deduced N/A Confident ab initio structure predictions are available.
    5 View Details [757..913] deduced N/A Confident ab initio structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  0.226078362275538 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.60

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle