Protein Overview: AAD3

General Information:
Name(s) found:	AAD3 / YCR107W [SGD]
Description(s) found: SHOW ONLY BEST	pir\|\|S19419 hypothetical protein YCR107w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|6319951\|ref\|NP_010032.1\| Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; Aad3p [Saccharomyces cerevisiae] [NCBI NR] gi\|1907245\|emb\|CAA42239.1\| hypotetical aryl-alcohol dehydrogenase [Saccharomyces cerevisiae] [NCBI NR] gi\|140566\|sp\|P25612.1\|AAD3_YEAST RecName: Full=Putative aryl-alcohol dehydrogenase AAD3 [NCBI NR] Putative aryl-alcohol dehydrogenase AAD3 OS=Saccharomyces cerevisiae GN=AAD3 PE=2 SV=1 [Swiss-Prot] AAD3 Aryl-alcohol dehydrogenase [mips] Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role [SGD] AAD3, Chr III from 313883-314974 [yeast_orfs2] Chr III from 313883-314974 [yeastorf3.fasta] (P25612) Putative aryl-alcohol dehydrogenase AAD3 (EC 1.1.1.-) [4932.FASTACCERV.txt] AAD3 SGDID:S0000704, Chr III from 313886-314977, Verified ORF [yeastflysequest.fasta] Aad3p [Saccharomyces cerevisiae]gi\|1907245\|emb\|CAA42239.1\| hypotetical aryl-alcohol dehydrogenase [Saccharomyces cerevisiae]gi\|83279\|pir\|\|S19419 hypothetical protein YCR107w - yeast (Saccharomyces cerevisiae)gi\|140566\|sp\|P25612\|AAD3_YEAST PUTATIVE ARYL [nrdb_11152004_Chlamydomonas] AAD3 SGDID:S000000704, Chr III from 313886-314977, Verified ORF, "Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] AAD3 SGDID:S000000704, Chr III from 313887-314978, Verified ORF, "Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role" [yeast-contam.fasta] hypotetical aryl-alcohol dehydrogenase [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Putative aryl-alcohol dehydrogenase AAD3 [nr-271106-contam.fasta] Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; Aad3p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] Putative aryl-alcohol dehydrogenase AAD3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AAD3 PE=2 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] AAD3 SGDID:S000000704, Chr III from 313890-314981, Genome Release 64-1-1, Verified ORF, "Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role" [yeast-030211-contam.fasta] Putative aryl-alcohol dehydrogenase AAD3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AAD3 PE=3 SV=1 [YEAST.fasta.20131015] AAD3 SGDID:S000000704, Chr III from 313890-314981, Genome Release 64-2-1, Verified ORF, "Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; AAD3 has a paralog, AAD15, that arose from a segmental duplication; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family" [20141208_orf_trans.fasta] YCR107W SGDID:S000000704, Chr III from 313890-314981, Genome Release 64-1-1, Verified ORF, "Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	363 amino acids
Gene Ontology:
Cellular Component:	cellular_component [ND]
Biological Process:	cellular aldehyde metabolic process [ISS]
Molecular Function:	aryl-alcohol dehydrogenase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIGSASDSSS KLGRLRFLSE TAAIKVSPLI LGEVSYDGAR SDFLKSMNKN RAFELLDTFY  60
   61 EAGGNFIDAA NNCQNEQSEE WIGEWIQSRR LRDQIVIATK FIKSDKKYKA GESNTANYCG 120
  121 NHKRSLHVSV RDSLRKLQTD WIDILYVHWW DYMSSIEEFM DSLHILVQQG KVLYLGVSDT 180
  181 PAWVVSAANY YATSYGKTPF SIYQGKWNVL NRDFERDIIP MARHFGMALA PWDVMGGGRF 240
  241 QSKKAMEERR KNGEGIRSFV GASEQTDAEI KISEALAKIA EEHGTESVTA IAIAYVRSKA 300
  301 KNFFPSVEGG KIEDLKENIK ALSIDLTPDN IKYLESIVPF DIGFPNNFIV LNSLTQKYGT 360
  361 NNV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#03 Alpha Factor Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CDC4	AAD3	1	Unpublished Fields Lab Data
View Screen	MET18	AAD3	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..236] [292..325]	PSI-BLAST	181.533179	Aflatoxin aldehyde reductase (akr7a1)
2	View Details	[237..291] [326..363]	PSI-BLAST	181.533179	Aflatoxin aldehyde reductase (akr7a1)

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
aldo-keto reductase activity	3.79117514230146	bayes_pls_golite062009
aryl-alcohol dehydrogenase activity	2.5168190536972	bayes_pls_golite062009
aldehyde reductase activity	2.19831490122079	bayes_pls_golite062009
catalytic activity	1.68179794468736	bayes_pls_golite062009
oxidoreductase activity	1.17915737521094	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.76912620964527	bayes_pls_golite062009
binding	0.750554688914866	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	0.731893663103321	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.95

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2