YRC Public Data Repository - Protein Structure Prediction

Protein:	AAD3
Organism:	Saccharomyces cerevisiae
Length:	363 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AAD3.

Description	E-value	Query Range	Subject Range
ALKR4_ARATH - Probable aldo-keto reductase 4 OS=Arabidopsis thaliana GN=At1g60710 PE=2 SV=1	6.0E-95	[10..354]	[7..330]
AAD14 - Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; ... AAD14_YEAST - Putative aryl-alcohol dehydrogenase AAD14 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) G...	2.0E-94	[1..357]	[4..360]
gi\|7471099 - pir\|\|E75296 aldo/keto reductase - Deinococcus radiodurans (strain R1) gi\|15807252, gi\|... - gi\|6460065\|gb\|AAF11806.1\|AE002058_6 aldo/keto reductase [Deinococcus radiodurans R1], gi\|15807252\|re...	3.0E-94	[23..356]	[11..327]
gi\|15075864 - gi\|15075864\|emb\|CAC47418.1\| Putative oxidoreductase [Sinorhizobium meliloti 1021] gi\|15966592 - gi\|15966592\|ref\|NP_386945.1\| putative oxidoreductase protein [Sinorhizobium meliloti 1021]	6.0E-94	[13..355]	[1..343]
gi\|15161953, gi\|... - gi\|16119421\|ref\|NP_396127.1\| hypothetical protein AGR_pAT_274 [Agrobacterium tumefaciens str. C58], ...	1.0E-93	[13..353]	[24..357]
gi\|126194344, gi... - gi\|254240966\|ref\|ZP_04934288.1\| hypothetical protein PA2G_01646 [Pseudomonas aeruginosa 2192], gi\|19... gi\|11351605 - pir\|\|H83328 probable oxidoreductase PA2535 [imported] - Pseudomonas aeruginosa (strain PAO1) gi\|218771712, gi... - gi\|218891486\|ref\|YP_002440353.1\| putative oxidoreductase [Pseudomonas aeruginosa LESB58], gi\|2187717... gi\|15597731, gi\|... - gi\|9948592\|gb\|AAG05923.1\|AE004681_5 probable oxidoreductase [Pseudomonas aeruginosa PAO1], gi\|155977...	1.0E-93	[13..348]	[1..321]
gi\|1773103, gi\|7... - gi\|7447925\|pir\|\|C64771 probable oxidoreductase (EC 1.-.-.-) yajO - Escherichia coli (strain K-12), g... gi\|16128404, gi\|... - gb\|AAC73522.1\| putative NAD(P)H-dependent xylose reductase; putative oxidoreductase, NAD(P)-dependen...	1.0E-93	[10..345]	[22..346]

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Predicted Domain #1

Region A:
Residues: [1-236]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIGSASDSSS KLGRLRFLSE TAAIKVSPLI LGEVSYDGAR SDFLKSMNKN RAFELLDTFY  60
   61 EAGGNFIDAA NNCQNEQSEE WIGEWIQSRR LRDQIVIATK FIKSDKKYKA GESNTANYCG 120
  121 NHKRSLHVSV RDSLRKLQTD WIDILYVHWW DYMSSIEEFM DSLHILVQQG KVLYLGVSDT 180
  181 PAWVVSAANY YATSYGKTPF SIYQGKWNVL NRDFERDIIP MARHFGMALA PWDVMG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [292-325]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AIAYVRSKAK NFFPSVEGGK IEDLKENIKA LSID

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	181.533179
Match:	1gveA_
Description:	Aflatoxin aldehyde reductase (akr7a1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
aldo-keto reductase activity	3.79117514230146	bayes_pls_golite062009
aryl-alcohol dehydrogenase activity	2.5168190536972	bayes_pls_golite062009
aldehyde reductase activity	2.19831490122079	bayes_pls_golite062009
catalytic activity	1.68179794468736	bayes_pls_golite062009
oxidoreductase activity	1.17915737521094	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.76912620964527	bayes_pls_golite062009
binding	0.750554688914866	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	0.731893663103321	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [237-291]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGRFQSKKAM EERRKNGEGI RSFVGASEQT DAEIKISEAL AKIAEEHGTE SVTAI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [326-363]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTPDNIKYLE SIVPFDIGFP NNFIVLNSLT QKYGTNNV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	181.533179
Match:	1gveA_
Description:	Aflatoxin aldehyde reductase (akr7a1)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: