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Protein Overview: FRM2

General Information:
Name(s) found: FRM2 / YCL026C-A [SGD]
Description(s) found:
Found 24 descriptions.
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  • Protein of unknown function, involved in the integration of lipid signaling pathways with cellular homeostasis; expression induced in cells treated with the mycotoxin patulin; has similarity to bacterial nitroreductases [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 193 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: negative regulation of fatty acid metabolic process [IMPLink to PubMed article]
    Molecular Function: NAD(P)H nitroreductase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPTGNYLNA ITNRRTIYNL KPELPQGVGL DDVKRTVHVI LKNTPTAFNS QVNRAVIIVG  60
   61 DTHKRIWDAV ASAMPTAEAK KRPESCRDEA YGSVIFFTDE GPTEKLQRDF PALAAAFPTC 120
  121 AAHTTGAVQI QSWTALELLG LGANLQHYND YVKSALPQDV PIAWTVQSQL VFGVPTALPE 180
  181 EKTFINNVIN VYH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data FRM2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..193] PSI-BLAST 21.69897 Flavin reductase P (NADPH:FMN oxidoreductase)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.88351700678 bayes_pls_golite062009
  • NAD(P)H nitroreductase activity
    		•  1.73743442947569 bayes_pls_golite062009
  • catalytic activity
    		•  1.11149969304282 bayes_pls_golite062009
  • protein binding
    		•  0.385179389448981 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.27929339949687 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle